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CS-W001157 4
Total: USD 88.00

Bis-​PEG2-​NHS ester

  • CAS No. 65869-63-8

  • Cat. No. CS-0104990
  • Purity≥97%
  • MDL No.MFCD20229443

*For research and further manufacturing use only, not for direct human use.

Bis-​PEG2-​NHS ester|CS-0104990

Structure of 65869-63-8

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General Information

  • CAS No. 65869-63-8
  • Cat. No. CS-0104990
  • Purity ≥97%
  • MDL No. MFCD20229443
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₂₀N₂O₁₀
  • Molecular Weight 400.34
  • Synonym(s) None
  • SMILES O=C(ON1C(CCC1=O)=O)CCOCCOCCC(ON2C(CCC2=O)=O)=O

Description

Bis-PEG2-NHS ester enables efficient, dual-functional conjugation in aqueous media. This bifunctional reagent features two NHS ester groups separated by a short PEG2 spacer, promoting stable amide bond formation with primary amines. The hydrophilic PEG linkage enhances solubility and reduces non-specific binding, making it ideal for protein labeling, peptide coupling, and bioconjugate synthesis under physiological conditions.

Application

Bis-PEG2-NHS ester serves as a bifunctional crosslinking agent enabling efficient conjugation of biomolecules and surface-bound amines. Its two PEG2 spacers provide enhanced solubility and reduced steric hindrance, while the NHS ester groups react selectively with primary amines under physiological conditions. Ideal for antibody-drug conjugation and bioconjugation workflows, it offers excellent stability in aqueous buffers and facilitates straightforward purification due to minimal byproduct formation.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   145.82
  • LogP   -0.9858
  • H_Acceptors   10
  • H_Donors   0
  • Rotatable_Bonds   11

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