Bis-PEG7-NHS ester

Name: Bis-PEG7-NHS ester
Brand: ChemScene
Availability: InStock
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CAS No. 1334170-02-3
Cat. No. CS-0107996
Purity≥95%
MDL No.MFCD18916987

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 1334170-02-3
Cat. No. CS-0107996
Purity ≥95%
MDL No. MFCD18916987
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₆H₄₀N₂O₁₅
Molecular Weight 620.60
Synonym(s) None
SMILES O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCOCCOCCC(ON2C(CCC2=O)=O)=O

Description

Bis-PEG7-NHS ester features two PEG7 chains flanking a reactive NHS ester group, enabling efficient conjugation to primary amines under physiological conditions. This bifunctional linker offers enhanced solubility and spacer length for bioconjugation applications, facilitating the creation of well-defined polymer-protein or polymer-drug architectures with minimal aggregation.

Application

Bis-PEG7-NHS ester serves as a bifunctional crosslinking agent enabling efficient conjugation of biomolecules and surface-bound reagents. Its two NHS ester groups react selectively with primary amines under physiological conditions, while the PEG7 spacer provides enhanced solubility and reduced steric hindrance. The molecule demonstrates excellent stability in aqueous environments and facilitates clean, high-yield coupling with minimal aggregation, making it ideal for applications in protein labeling, immunoassay development, and bioconjugate synthesis.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 191.97
LogP -0.9028
H_Acceptors 15
H_Donors 0
Rotatable_Bonds 26

Other Classifications

Life Science Linker Bis-PEG-NHS

Life Science ADC Related Compound Cleavable Linker

Building Blocks Functional Group PEG

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Chemical Biology PEGylation Monofunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation Heterobifunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Biochemicals and Reagents Bioconjugation PEGylation Reagents and PEG Spacers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Key Words

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Bis-PEG7-NHS ester

CAS No. 1334170-02-3

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