Bis-PEG3-NHS ester

Name: Bis-PEG3-NHS ester
Brand: ChemScene
Availability: InStock
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CAS No. 1314378-16-9
Cat. No. CS-0104989
Purity≥97%
MDL No.MFCD20227484

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 1314378-16-9
Cat. No. CS-0104989
Purity ≥97%
MDL No. MFCD20227484
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₈H₂₄N₂O₁₁
Molecular Weight 444.39
Synonym(s) None
SMILES O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCC(ON2C(CCC2=O)=O)=O

Description

Bis-PEG3-NHS ester features two reactive NHS groups separated by a triethylene glycol spacer, enabling efficient conjugation to primary amines under physiological conditions. This bifunctional linker offers enhanced solubility and stability in aqueous media, facilitating site-specific bioconjugation in protein labeling, antibody-drug conjugate synthesis, and surface immobilization applications.

Application

Bis-PEG3-NHS ester serves as a bifunctional crosslinking agent enabling efficient conjugation of biomolecules and synthetic polymers. The NHS ester groups react selectively with primary amines under physiological conditions, while the PEG3 spacer provides enhanced solubility and reduced non-specific binding. This reagent facilitates site-specific labeling and functionalization in protein bioconjugation, peptide modification, and surface immobilization applications, offering excellent stability and ease of purification.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 155.05
LogP -0.9692
H_Acceptors 11
H_Donors 0
Rotatable_Bonds 14

Other Classifications

Life Science Linker Bis-PEG-NHS

Life Science ADC Related Compound Non-cleavable linker

Building Blocks Functional Group PEG

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Chemical Biology PEGylation Monofunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation Heterobifunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Biochemicals and Reagents Bioconjugation PEGylation Reagents and PEG Spacers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Key Words

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Bis-PEG3-NHS ester

CAS No. 1314378-16-9

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