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CS-W001157 4
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(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanamine

  • CAS No. 138500-88-6

  • Cat. No. CS-0130396
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanamine|CS-0130396

Structure of 138500-88-6

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General Information

  • CAS No. 138500-88-6
  • Cat. No. CS-0130396
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₀BNO₂
  • Molecular Weight 233.11
  • Synonym(s) (4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanamine hydrochloride
  • SMILES NCC1=CC=C(C=C1)B2OC(C)(C(C)(O2)C)C

Description

This boronate-functionalized arylmethylamine integrates seamlessly into Suzuki-Miyaura coupling reactions under standard conditions. The tetramethyl-1,3,2-dioxaborolane moiety ensures high stability and moisture tolerance, while the primary amine group enables direct conjugation or derivatization. Ideal for constructing complex biaryl architectures in medicinal chemistry and materials synthesis.

Synthesis

  • Route1

    References

    • Molecules, , vol. 18, # 10 p. 12346 - 12367
  • Route2

    References

    • Organic Letters, , vol. 15, # 18 p. 4850 - 4853
  • Route3

    References

    • Molecules, , vol. 18, # 10 p. 12346 - 12367

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   44.48
  • LogP   1.4445
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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