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CS-W001157 4
Total: USD 88.00

N-Mal-N-bis(PEG2-NHS ester)

  • CAS No. 2182601-73-4

  • Cat. No. CS-0115088
  • Purity≥98%
  • MDL No.MFCD29912828

*For research and further manufacturing use only, not for direct human use.

N-Mal-N-bis(PEG2-NHS ester)|CS-0115088

Structure of 2182601-73-4

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General Information

  • CAS No. 2182601-73-4
  • Cat. No. CS-0115088
  • Purity ≥98%
  • MDL No. MFCD29912828
  • Storage -20°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₉H₃₈N₄O₁₅
  • Molecular Weight 682.63
  • Synonym(s) None
  • SMILES O=C(ON1C(CCC1=O)=O)CCOCCOCCN(C(CCN2C(C=CC2=O)=O)=O)CCOCCOCCC(ON3C(CCC3=O)=O)=O

Description

N-Mal-N-bis(PEG2-NHS ester) delivers a dual reactive handle for site-specific conjugation, combining maleimide’s affinity for thiols with NHS ester’s reactivity toward amines. This bifunctional linker enables efficient, orthogonal coupling in biomolecule labeling and protein-polymer hybrid synthesis under physiological conditions.

Application

N-Mal-N-bis(PEG2-NHS ester) serves as a bifunctional crosslinker enabling efficient conjugation of maleimide-reactive thiol groups with amine-containing biomolecules. The PEG2 spacer enhances solubility and reduces steric hindrance, while the NHS ester moiety facilitates rapid coupling to primary amines under physiological conditions. This reagent offers excellent stability in aqueous buffers and simplifies purification due to its hydrophilic nature, making it ideal for site-specific bioconjugation in antibody-drug conjugate (ADC) development and protein labeling workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   221.97
  • LogP   -1.8089
  • H_Acceptors   15
  • H_Donors   0
  • Rotatable_Bonds   23

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