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CS-W001157 4
Total: USD 88.00

Mal-PEG8-NHS ester

  • CAS No. 2055033-05-9

  • Cat. No. CS-0107989
  • Purity≥95%
  • MDL No.MFCD26127784
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Mal-PEG8-NHS ester|CS-0107989

Structure of 2055033-05-9

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Description

Mal-PEG8-NHS ester is a bifunctional crosslinker featuring a maleimide group and a reactive NHS ester, separated by an 8-unit PEG spacer. This design enables efficient conjugation to thiol-containing biomolecules and amine-functionalized surfaces under physiological conditions. The hydrophilic PEG chain minimizes non-specific binding and enhances solubility in aqueous environments.

Application

Mal-PEG8-NHS ester serves as a versatile bifunctional linker for site-specific conjugation, combining the reactive maleimide group with a hydrophilic PEG8 spacer and an NHS ester for amine coupling. It enables efficient, orthogonal bioconjugation in aqueous conditions, offering enhanced stability and reduced aggregation compared to shorter PEG chains. Ideal for antibody-drug conjugate (ADC) synthesis and protein labeling, it facilitates reliable conjugation with minimal side reactions.

General Information

  • CAS No. 2055033-05-9
  • Cat. No. CS-0107989
  • Purity ≥95%
  • MDL No. MFCD26127784
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₇H₄₂N₂O₁₄
  • Molecular Weight 618.63
  • Synonym(s) None
  • SMILES O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCOCCOCCOCCN2C(C=CC2=O)=O

Computational Chemistry Data

  • TPSA   174.9
  • LogP   -0.9585
  • H_Acceptors   14
  • H_Donors   0
  • Rotatable_Bonds   28

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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