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CS-W001157 4
Total: USD 88.00

Boc-Lys(Fmoc)-OH

  • CAS No. 84624-27-1

  • Cat. No. CS-W005144
  • Purity≥98%
  • MDL No.MFCD00062032

*For research and further manufacturing use only, not for direct human use.

Boc-Lys(Fmoc)-OH|CS-W005144

Structure of 84624-27-1

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General Information

  • CAS No. 84624-27-1
  • Cat. No. CS-W005144
  • Purity ≥98%
  • MDL No. MFCD00062032
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₆H₃₂N₂O₆
  • Molecular Weight 468.54
  • Synonym(s) None
  • SMILES O=C(O)[C@H](CCCCNC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)NC(OC(C)(C)C)=O

Description

Boc-Lys(Fmoc)-OH is a protected lysine derivative featuring orthogonal side-chain and α-amino group masking. The Fmoc moiety enables base-labile deprotection in solid-phase peptide synthesis, while the Boc group provides stable protection of the ε-amino function under acidic conditions. This dual protection strategy facilitates selective functionalization and efficient incorporation into complex peptide sequences.

Application

Boc-Lys(Fmoc)-OH serves as a key di-functional amino acid building block for peptide synthesis, enabling orthogonal protection of both α-amino and ε-amino groups. The Boc group provides stable Nα-protection suitable for acid-labile deprotection, while the Fmoc moiety allows for mild base-cleavable side-chain protection. This dual protection strategy facilitates efficient sequential coupling in solid-phase peptide synthesis, supports high-purity product formation, and simplifies purification due to enhanced solubility and chromatographic behavior.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   113.96
  • LogP   4.6733
  • H_Acceptors   5
  • H_Donors   3
  • Rotatable_Bonds   9

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