Lot numbers can be found on the outside label of a product:
5-Bromo-2-chloronicotinonitrile
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CAS No. 405224-23-9
- Cat. No. CS-W003648
- Purity≥98%
- MDL No.MFCD09801046
*For research and further manufacturing use only, not for direct human use.
Structure of 405224-23-9
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General Information
- CAS No. 405224-23-9
- Cat. No. CS-W003648
- Purity ≥98%
- MDL No. MFCD09801046
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₆H₂BrClN₂
- Molecular Weight 217.45
- Synonym(s) 5-bromo-2-chloropyridine-3-carbonitrile
- SMILES N#Cc1cc(Br)cnc1Cl
Description
Polyethyleneimine is used for protein and nucleic acid precipitation, transfection assays, and to pretreat filters to increase the binding of proteins. Polyethyleneimine can also complex heavy metal ions. An effective permeabilizer of gram negative bacteria. Crosslinked polyethyleneimine is used as an enzyme carrier. Polyethyleneimine cellulose in small columns will separate cyclic nucleotides from related compounds at the same electrolyte concentration that is used for thin layer chromatography on Polyethyleneimine cellulose-coated plates. It is a water soluble polymer used as a membrane lubricant, useful in filtering frozen cell membranes.
Application
5-Bromo-2-chloronicotinonitrile serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The nitrile group provides a handle for further functionalization, while the ortho-chloro and meta-bromo substituents offer orthogonal sites for selective transformations. Its bench-stable nature and compatibility with standard synthetic protocols facilitate efficient construction of complex heterocyclic scaffolds and API intermediates.
Synthesis
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Route1
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In-stock
709652-82-4 - ~88%
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In-stock
405224-23-9
References
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VITAS PHARMA RESEARCH PRIVATE LIMITED; RANGARAJAN, Radha; KUMAR, Rajinder; PRABHAKAR, B V; CHANDRASEKHAR, P; MALLIKARJUNA, P; BANERJEE, Ankita Patent: WO2013/42035 A1, 2013 ; Location in patent: Page/Page column 17 ;
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Route2
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In-stock
405224-22-8 - ~93%
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In-stock
405224-23-9
References
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Witherington, Jason; Bordas, Vincent; Garland, Stephen L.; Hickey, Deirdre M. B.; Ife, Robert J.; Liddle, John; Saunders, Martin; Smith, David G.; Ward, Robert W. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 9 p. 1577 - 1580
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Route3
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In-stock
20577-27-9 - ~%
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In-stock
405224-23-9
References
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Huart, Anne-Sophie; Saxty, Barbara; Merritt, Andy; Nekulova, Marta; Lewis, Stephen; Huang, Yide; Vojtesek, Borivoj; Kettleborough, Catherine; Hupp, Ted R. Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 20 p. 5578 - 5585
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS05,GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H315-H318-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 36.68
- LogP 2.36918
- H_Acceptors 2
- H_Donors 0
- Rotatable_Bonds 0
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Key Words
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