Benzyl 4-(2-hydroxyethyl)piperidine-1-carboxylate

Name: Benzyl 4-(2-hydroxyethyl)piperidine-1-carboxylate
Brand: ChemScene
Availability: InStock
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CAS No. 115909-91-6
Cat. No. CS-0171374
Purity≥97%
MDL No.MFCD04114976

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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Benzyl 4-(2-hydroxyethyl)piperidine-1-carboxylate|CS-0171374

Structure of 115909-91-6

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General Information

CAS No. 115909-91-6
Cat. No. CS-0171374
Purity ≥97%
MDL No. MFCD04114976
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₅H₂₁NO₃
Molecular Weight 263.34
Synonym(s) None
SMILES O=C(OCC=1C=CC=CC1)N2CCC(CCO)CC2

Description

Benzyl 4-(2-hydroxyethyl)piperidine-1-carboxylate features a piperidine core functionalized with a hydroxyethyl side chain and a benzyl ester group, enabling selective derivatization. This scaffold offers enhanced solubility and stability under standard conditions, facilitating its use in medicinal chemistry campaigns targeting CNS disorders and kinase inhibition.

Application

Benzyl 4-(2-hydroxyethyl)piperidine-1-carboxylate serves as a versatile synthetic intermediate for piperidine-based scaffolds. The pendant hydroxyl group enables facile derivatization via esterification, etherification, or oxidation to carboxylic acid, while the benzyl ester offers orthogonal protection and ease of removal under mild hydrogenolysis conditions. Its stability, compatibility with standard coupling reactions, and utility in building complex heterocyclic architectures make it a practical choice for medicinal chemistry and process development workflows.

Synthesis

Route1
- In-stock
  
  622-26-4
- 501-53-1
- ~78%
- In-stock
  
  115909-91-6
References
- F. HOFFMANN-LA ROCHE AG Patent: WO2005/5397 A1, 2005 ; Location in patent: Page/Page column 61 ; WO 2005/005397 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 49.77
LogP 2.4176
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 4

Other Classifications

Building Blocks Functional Group Ester

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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Benzyl 4-(2-hydroxyethyl)piperidine-1-carboxylate

CAS No. 115909-91-6

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