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CS-W001157 4
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4-Bromo-2-fluoro-3-methoxybenzaldehyde

  • CAS No. 1820614-17-2

  • Cat. No. CS-0134965
  • Purity≥97%
  • MDL No.MFCD27578163

*For research and further manufacturing use only, not for direct human use.

4-Bromo-2-fluoro-3-methoxybenzaldehyde|CS-0134965

Structure of 1820614-17-2

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General Information

  • CAS No. 1820614-17-2
  • Cat. No. CS-0134965
  • Purity ≥97%
  • MDL No. MFCD27578163
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆BrFO₂
  • Molecular Weight 233.03
  • Synonym(s) None
  • SMILES O=CC1=CC=C(Br)C(OC)=C1F

Description

This electron-deficient aldehyde features a para-fluoro substituent and a methoxy group, enabling selective coupling reactions in synthetic organic chemistry. The bromo handle facilitates cross-coupling transformations, while the bench-stable aldehyde moiety supports efficient derivatization under standard conditions.

Application

4-Bromo-2-fluoro-3-methoxybenzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling the construction of substituted benzimidazoles, pyridines, and other heterocyclic scaffolds. Its orthogonal functional groups—bromine, fluorine, methoxy, and aldehyde—support diverse downstream transformations including Suzuki-Miyaura coupling, nucleophilic addition, and electrophilic substitution. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for scalable process development.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   2.4093
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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