2-Bromo-5-chloropyrazolo[1,5-a]pyrimidine

Name: 2-Bromo-5-chloropyrazolo[1,5-a]pyrimidine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1780378-34-8
Cat. No. CS-0137916
Purity≥96%
MDL No.MFCD20258252

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Bromo-5-chloropyrazolo[1,5-a]pyrimidine|CS-0137916

Structure of 1780378-34-8

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General Information

CAS No. 1780378-34-8
Cat. No. CS-0137916
Purity ≥96%
MDL No. MFCD20258252
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃BrClN₃
Molecular Weight None
Synonym(s) None
SMILES ClC1=NC2=CC(Br)=NN2C=C1

Description

2-Bromo-5-chloropyrazolo[1,5-a]pyrimidine features a fused heterocyclic core with complementary halogen substituents enabling direct functionalization in cross-coupling reactions. The electron-deficient pyrazolopyrimidine scaffold supports efficient derivatization under palladium catalysis, delivering complex molecular architectures for medicinal chemistry and materials science applications.

Application

2-Bromo-5-chloropyrazolo[1,5-a]pyrimidine serves as a versatile building block for constructing substituted heterocycles in medicinal chemistry and agrochemical research. Its dual halogenation enables efficient Pd-catalyzed cross-coupling reactions, including Suzuki-Miyaura and Buchwald-Hartwig aminations, with excellent functional group tolerance. The molecule exhibits good bench stability and facilitates rapid diversification of pyrazolo[1,5-a]pyrimidine scaffolds under standard reaction conditions.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 30.19
LogP 2.1452
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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2-Bromo-5-chloropyrazolo[1,5-a]pyrimidine

CAS No. 1780378-34-8

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