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CS-W001157 4
Total: USD 88.00

N-Boc-4-Piperidineethanol

  • CAS No. 89151-44-0

  • Cat. No. CS-M1539
  • Purity≥97%
  • MDL No.MFCD03427086

*For research and further manufacturing use only, not for direct human use.

N-Boc-4-Piperidineethanol|CS-M1539

Structure of 89151-44-0

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General Information

  • CAS No. 89151-44-0
  • Cat. No. CS-M1539
  • Purity ≥97%
  • MDL No. MFCD03427086
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₃NO₃
  • Molecular Weight 229.32
  • Synonym(s) Tert-butyl 4-(2-hydroxyethyl)piperidine-1-carboxylate; N-Boc-4-piperidineethanol
  • SMILES O=C(N1CCC(CCO)CC1)OC(C)(C)C

Description

N-Boc-4-Piperidineethanol features a protected piperidine ring with a terminal hydroxymethyl group, enabling straightforward deprotection and functionalization. This bench-stable derivative integrates readily into medicinal chemistry campaigns, serving as a key scaffold for bioactive molecule synthesis.

Application

N-Boc-4-Piperidineethanol serves as a versatile building block in medicinal chemistry, enabling efficient construction of piperidine-containing scaffolds. The Boc-protected amine offers excellent bench stability and compatibility with standard deprotection protocols, while the terminal hydroxyl group facilitates derivatization via esterification or ether formation. Its defined stereochemistry and functional group tolerance make it ideal for modular synthesis of bioactive compounds and API intermediates.

Synthesis

  • Route1

    References

    • Tetrahedron Letters, , vol. 47, # 15 p. 2515 - 2516
  • Route2

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 13 p. 2167 - 2172
  • Route3

    References

    • EP1640369 A1, ; Page/Page column 31 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   49.77
  • LogP   2.0159
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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