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CS-W001157 4
Total: USD 88.00

2-(1-Methylpiperidin-4-yl)ethan-1-ol

  • CAS No. 21156-84-3

  • Cat. No. CS-0052318
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(1-Methylpiperidin-4-yl)ethan-1-ol|CS-0052318

Structure of 21156-84-3

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General Information

  • CAS No. 21156-84-3
  • Cat. No. CS-0052318
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₇NO
  • Molecular Weight 143.23
  • Synonym(s) 2-(1-Methylpiperidin-4-yl)ethanol
  • SMILES CN1CCC(CCO)CC1

Description

This piperidine derivative features a flexible ethan-1-ol tether linking a 1-methylpiperidin-4-yl group to a hydroxyl-bearing carbon. The primary alcohol enables straightforward derivatization, while the tertiary amine imparts solubility and basic character. Designed for modular synthesis in medicinal chemistry, this scaffold integrates readily into bioactive molecules requiring balanced polarity and metabolic stability under standard bench conditions.

Application

2-(1-Methylpiperidin-4-yl)ethan-1-ol serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive scaffolds through standard coupling and functionalization reactions. Its piperidine core offers favorable solubility and metabolic stability, while the primary alcohol facilitates derivatization via esterification, etherification, or oxidation to aldehyde. The molecule exhibits bench stability and compatibility with common reaction conditions, supporting efficient synthesis workflows in API development and target-oriented synthesis.

Synthesis

  • Route1
    • In-stock
      2-(Piperidin-4-yl)ethan-1-ol|CS-W013445
      622-26-4
    • null|null
      50-00-0
    • ~%
    • In-stock
      2-(1-Methylpiperidin-4-yl)ethan-1-ol|CS-0052318
      21156-84-3

    References

    • Biovitrum AB Patent: US2009/281087 A1, 2009 ; Location in patent: Page/Page column 15 ;
  • Route2
    • null|null
      185942-85-2
    • ~%
    • In-stock
      2-(1-Methylpiperidin-4-yl)ethan-1-ol|CS-0052318
      21156-84-3

    References

    • Nisshin Flour Milling Co., Ltd. Patent: US5945434 A1, 1999 ;
  • Route3
    • 2-(Pyridin-4-yl)ethanol Betahistine  Impurity|CS-0228836
      5344-27-4
    • ~%
    • In-stock
      2-(1-Methylpiperidin-4-yl)ethan-1-ol|CS-0052318
      21156-84-3

    References

    • Burtner; Brown Journal of the American Chemical Society, 1947 , vol. 69, p. 630,631

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   23.47
  • LogP   0.7106
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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