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CS-W001157 4
Total: USD 88.00

1-Benzylpiperidine-4-carboxylic acid

  • CAS No. 10315-07-8

  • Cat. No. CS-W001281
  • Molecule weight219.28
  • Purity≥97%
  • MDL No.MFCD03371463

*For research and further manufacturing use only, not for direct human use.

1-Benzylpiperidine-4-carboxylic acid|CS-W001281

Structure of 10315-07-8

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General Information

  • CAS No. 10315-07-8
  • Cat. No. CS-W001281
  • Purity ≥97%
  • MDL No. MFCD03371463
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₇NO₂
  • Molecular Weight 219.28
  • Synonym(s) N-Benzyl-Isonipecotic acid
  • SMILES OC(=O)C1CCN(CC1)Cc1ccccc1

Description

1-Benzylpiperidine-4-carboxylic acid features a rigid, electron-rich piperidine core functionalized with a benzyl group and a carboxylic acid at the 4-position. This combination enables direct integration into bioactive scaffolds, offering enhanced solubility and metabolic stability in medicinal chemistry applications.

Application

1-Benzylpiperidine-4-carboxylic acid serves as a versatile scaffold for medicinal chemistry campaigns, enabling the construction of bioactive heterocycles through standard amide coupling and reduction protocols. Its benzylated piperidine core provides enhanced metabolic stability and favorable lipophilicity, while the carboxylic acid group facilitates direct conjugation or derivatization in peptide and macrocyclic synthesis. The compound exhibits good bench stability and is readily purified by recrystallization or flash chromatography.

Synthesis

  • Route1

    References

    • Chen, Zecheng; Venkatesan, Aranapakam M.; Dehnhardt, Christoph M.; Santos, Osvaldo Dos; Santos, Efren Delos; Ayral-Kaloustian, Semiramis; Chen, Lei; Geng, Yi; Arndt, Kim T.; Lucas, Judy; Chaudhary, Inder; Mansour, Tarek S. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 17 p. 4980 - 4983
  • Route2
    • null|null
      123-91-1
    • In-stock
      Ethyl N-benzylpiperidine-4-carboxylate|CS-M0322
      24228-40-8
    • ~%
    • In-stock
      1-Benzylpiperidine-4-carboxylic acid|CS-W001281
      10315-07-8

    References

    • US5753679 A1, ;
  • Route3

    References

    • EP520336 A2, ; EP 0520336 A2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   40.54
  • LogP   1.9832
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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