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CS-W001157 4
Total: USD 88.00

Boc-Inp-OH

  • CAS No. 84358-13-4

  • Cat. No. CS-B0844
  • Purity≥97%
  • MDL No.MFCD00076999

*For research and further manufacturing use only, not for direct human use.

Boc-Inp-OH|CS-B0844

Structure of 84358-13-4

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General Information

  • CAS No. 84358-13-4
  • Cat. No. CS-B0844
  • Purity ≥97%
  • MDL No. MFCD00076999
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₉NO₄
  • Molecular Weight 229.27
  • Synonym(s) 1-Boc-Piperidine-4-carboxylic acid
  • SMILES O=C(OC(C)(C)C)N(CC1)CCC1C(O)=O

Description

Boc-Inp-OH features a protected indole nucleus with a pendant hydroxyl group, enabling selective functionalization in peptide and heterocyclic synthesis. This bench-stable derivative integrates readily into complex molecular architectures under standard conditions.

Application

Boc-Inp-OH serves as a versatile building block for the synthesis of indole-containing scaffolds, enabling direct incorporation of protected indole units into peptide and small-molecule libraries. Its stability under standard coupling conditions and compatibility with common deprotection protocols facilitate efficient access to functionalized indoles. Functions effectively in solid-phase and solution-phase syntheses, supporting diverse transformations including C–H activation and Pd-catalyzed couplings.

Synthesis

  • Route1

    References

    • Su, Weiguo; Zhang, Weihan; Yang, Haibin Patent: US2013/190307 A1, 2013 ; Location in patent: Paragraph 0205; 0206 ;
  • Route2

    References

    • ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA Patent: WO2006/21449 A1, 2006 ; Location in patent: Page/Page column 8; 9 ;
  • Route3
    • Piperidine-4-carboxylic acid Avatrombopag Impurity|CS-0377512
      498-94-2
    • In-stock
      Di-tert-butyl dicarbonate|CS-0017817
      24424-99-5
    • ~99%
    • In-stock
      Boc-Inp-OH|CS-B0844
      84358-13-4

    References

    • Aventis Pharmaceuticals Inc.; Aventis Pharma Deutschland GmbH Patent: US2005/261341 A1, 2005 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   1.7181
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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