Lot numbers can be found on the outside label of a product:
Ethyl N-benzylpiperidine-4-carboxylate
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CAS No. 24228-40-8
- Cat. No. CS-M0322
- Purity≥98%
- MDL No.MFCD00040748
*For research and further manufacturing use only, not for direct human use.
Structure of 24228-40-8
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General Information
- CAS No. 24228-40-8
- Cat. No. CS-M0322
- Purity ≥98%
- MDL No. MFCD00040748
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₅H₂₁NO₂
- Molecular Weight None
- Synonym(s) N-BENZYL-4-CARBETHOXY PIPERIDINE
- SMILES O=C(OCC)C1CCN(CC2=CC=CC=C2)CC1
Description
Ethyl N-benzylpiperidine-4-carboxylate features a rigid piperidine core functionalized with a benzyl group at nitrogen and an ester handle at the 4-position. This configuration supports direct incorporation into medicinal chemistry scaffolds, enabling efficient derivatization under standard conditions. The molecule exhibits favorable solubility in organic media and stability during routine handling.
Application
Ethyl N-benzylpiperidine-4-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to piperidine-based scaffolds. The ester functionality facilitates downstream transformations such as hydrolysis, reduction, or coupling reactions, while the N-benzyl group provides steric and electronic modulation. Its bench-stable nature and compatibility with standard synthetic protocols make it well-suited for iterative synthesis and process development.
Synthesis
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Route1
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In-stock
1126-09-6 -
100-39-0 - ~94%
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In-stock
24228-40-8
References
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Hu, Essa; Kunz, Roxanne K.; Rumfelt, Shannon; Hitchcock, Stephen A.; Lindstrom, Michelle; Treanor, James; Andrews, Kristin L.; Li, Chun Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 22 p. 6938 - 6942,5
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Route2
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In-stock
1126-09-6
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100-44-7
- ~96%
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In-stock
24228-40-8
References
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O'Brien, Christopher J.; Nixon, Zachary S.; Holohan, Andrew J.; Kunkel, Stephen R.; Tellez, Jennifer L.; Doonan, Bryan J.; Coyle, Emma E.; Lavigne, Florie; Kang, Lauren J.; Przeworski, Katherine C. Chemistry - A European Journal, 2013 , vol. 19, # 45 p. 15281 - 15289
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Route3
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136081-74-8 - ~81%
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In-stock
24228-40-8
References
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Barbe, Guillaume; Charette, Andre B. Journal of the American Chemical Society, 2008 , vol. 130, # 1 p. 18 - 19
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2810
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301
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Precautionary Statements : P264-P270-P301+P310-P330-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 29.54
- LogP 2.4617
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 4
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Key Words
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