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CS-W001157 4
Total: USD 88.00

H-Glu(OtBu)-OBzl.HCl

  • CAS No. 98102-32-0

  • Cat. No. CS-0154840
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

H-Glu(OtBu)-OBzl.HCl|CS-0154840

Structure of 98102-32-0

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General Information

  • CAS No. 98102-32-0
  • Cat. No. CS-0154840
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₂₄ClNO₄
  • Molecular Weight 329.82
  • Synonym(s) H-GLU(OTBU)- OBZL.HCL
  • SMILES CC(C)(C)OC(=O)CC[C@@H](C(=O)OCC1=CC=CC=C1)N.Cl

Description

H-Glu(OtBu)-OBzl.HCl is a protected glutamic acid derivative featuring a tert-butyl ester and benzyl ether group, offering enhanced stability and solubility in organic solvents. This orthogonal protection scheme facilitates selective deprotection during peptide synthesis, enabling efficient access to functionalized glutamate residues under standard conditions.

Application

H-Glu(OtBu)-OBzl.HCl serves as a versatile, bench-stable building block for the synthesis of peptide-based pharmaceutical intermediates and complex heterocyclic scaffolds. The side-chain γ-carboxyl group is protected as a tert-butyl ester, while the α-amino group is protonated as a hydrochloride salt, enabling straightforward coupling reactions and orthogonal deprotection sequences. Its compatibility with standard Fmoc and Boc solid-phase peptide synthesis protocols facilitates efficient incorporation into target molecules.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   78.62
  • LogP   2.6008
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   6

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