Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

3-(Difluoromethoxy)pyridin-2-amine

  • CAS No. 947249-14-1

  • Cat. No. CS-D0412
  • Purity≥97%
  • MDL No.MFCD12405788

*For research and further manufacturing use only, not for direct human use.

3-(Difluoromethoxy)pyridin-2-amine|CS-D0412

Structure of 947249-14-1

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 947249-14-1
  • Cat. No. CS-D0412
  • Purity ≥97%
  • MDL No. MFCD12405788
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆F₂N₂O
  • Molecular Weight 160.12
  • Synonym(s) 3-(Difluoromethoxy)-2-pyridinamine
  • SMILES NC1=NC=CC=C1OC(F)F

Description

3-(Difluoromethoxy)pyridin-2-amine features a pyridine scaffold bearing a difluoromethoxy group at the 3-position and an amino function at the 2-position, delivering enhanced electron density and improved solubility in polar solvents. This configuration supports efficient coupling reactions and enables access to advanced intermediates in medicinal chemistry.

Application

3-(Difluoromethoxy)pyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling reactions. Its difluoromethoxy group imparts enhanced metabolic stability and modulated lipophilicity, while the pyridin-2-amine functionality facilitates efficient derivatization via Suzuki-Miyaura, Buchwald-Hartwig, or electrophilic substitution. The compound exhibits good bench stability and is readily purified by chromatography or crystallization, supporting scalable synthesis and integration into complex molecular architectures.

Synthesis

  • Route1
    • 3-(Difluoromethoxy)-2-nitropyridine|CS-0107290
      1111637-77-4
    • ~96%
    • In-stock
      3-(Difluoromethoxy)pyridin-2-amine|CS-D0412
      947249-14-1

    References

    • NOVARTIS AG; HUANG, Zilin; SENDZIK, Martin Patent: WO2010/100127 A1, 2010 ; Location in patent: Page/Page column 73 ; WO 2010/100127 A1
  • Route2

    References

    • NOVARTIS AG Patent: WO2009/115572 A2, 2009 ; Location in patent: Page/Page column 125-126 ; WO 2009/115572 A2
  • Route3

    References

    • Huang, Zilin; Jin, Jeff; Machajewski, Timothy; Antonios-McCrea, William R.; McKenna, Maureen; Poon, Daniel; Renhowe, Paul A.; Sendzik, Martin; Shafer, Cynthia; Smith, Aaron; Xu, Yongjin; Zhang, Qiong; Chen, Zheng Patent: US2013/210818 A1, 2013 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   48.14
  • LogP   1.2652
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 3-(Difluoromethoxy)pyridin-2-amine sigma3-(Difluoromethoxy)pyridin-2-amine manufacturer3-(Difluoromethoxy)pyridin-2-amine price3-(Difluoromethoxy)pyridin-2-amine structure3-(Difluoromethoxy)pyridin-2-amine SDSbuy 3-(Difluoromethoxy)pyridin-2-amine3-(Difluoromethoxy)pyridin-2-amine supplier3-(Difluoromethoxy)pyridin-2-amine uses3-(Difluoromethoxy)pyridin-2-amine molecular weightprice of 3-(Difluoromethoxy)pyridin-2-amine3-(Difluoromethoxy)pyridin-2-amine chemical name formula of 3-(Difluoromethoxy)pyridin-2-amine
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label