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CS-W001157 4
Total: USD 88.00

5-(Difluoromethoxy)pyridin-2-amine

  • CAS No. 110861-14-8

  • Cat. No. CS-0132705
  • Purity≥96%
  • MDL No.MFCD11977404

*For research and further manufacturing use only, not for direct human use.

5-(Difluoromethoxy)pyridin-2-amine|CS-0132705

Structure of 110861-14-8

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General Information

  • CAS No. 110861-14-8
  • Cat. No. CS-0132705
  • Purity ≥96%
  • MDL No. MFCD11977404
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆F₂N₂O
  • Molecular Weight 160.12
  • Synonym(s) 5-Difluoromethoxy-pyridin-2-ylamine
  • SMILES NC1=NC=C(OC(F)F)C=C1

Description

5-(Difluoromethoxy)pyridin-2-amine features a pyridine core functionalized with a difluoromethoxy group at the 5-position and an amino substituent at the 2-position. This electron-rich heterocycle integrates readily into pharmaceutical scaffolds, offering enhanced metabolic stability and improved solubility in polar solvents. The para-oriented amine enables efficient coupling reactions under standard conditions.

Application

5-(Difluoromethoxy)pyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard coupling reactions. Its difluoromethoxy group imparts enhanced metabolic stability and modulated lipophilicity, while the pyridin-2-amine moiety facilitates efficient Suzuki-Miyaura, Ullmann, or Buchwald-Hartwig couplings. The compound exhibits good bench stability and is readily purified by chromatography, making it well-suited for iterative scaffold elaboration in API discovery workflows.

Synthesis

  • Route1
    • null|null
      110861-12-6
    • ~55%
    • In-stock
      5-(Difluoromethoxy)pyridin-2-amine|CS-0132705
      110861-14-8

    References

    • Fuss, Andreas; Koch, Volker Synthesis, 1990 , # 8 p. 681 - 685
  • Route2
    • null|null
      35771-41-6
    • ~%
    • In-stock
      5-(Difluoromethoxy)pyridin-2-amine|CS-0132705
      110861-14-8

    References

    • Fuss, Andreas; Koch, Volker Synthesis, 1990 , # 8 p. 681 - 685

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   1.2652
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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