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CS-W001157 4
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2-Amino-5-methoxypyridine

  • CAS No. 10167-97-2

  • Cat. No. CS-D1544
  • Purity≥98%
  • MDL No.MFCD07374873

*For research and further manufacturing use only, not for direct human use.

2-Amino-5-methoxypyridine|CS-D1544

Structure of 10167-97-2

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General Information

  • CAS No. 10167-97-2
  • Cat. No. CS-D1544
  • Purity ≥98%
  • MDL No. MFCD07374873
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂O
  • Molecular Weight None
  • Synonym(s) 5-Methoxy-2-pyridinamine; 2-Amino-5-methoxypyridine; 5-Methoxy-2-aminopyridine; 5-Methoxypyridin-2-amine; 5-METHOXY-PYRIDIN-2-YLAMINE
  • SMILES NC1=NC=C(OC)C=C1

Description

2-Amino-5-methoxypyridine is a heterocyclic building block featuring an electron-rich pyridine core with complementary amino and methoxy substituents. This configuration enables direct functionalization at multiple sites, facilitating integration into pharmaceutical intermediates and agrochemical scaffolds. The molecule exhibits enhanced solubility in polar solvents and stability under standard handling conditions.

Application

2-Amino-5-methoxypyridine serves as a versatile building block in medicinal chemistry, enabling the construction of pyridine-based scaffolds through Suzuki-Miyaura and Buchwald-Hartwig couplings. Its amino and methoxy groups offer orthogonal reactivity for sequential functionalization, while the compound exhibits excellent bench stability and ease of purification, making it well-suited for scale-up and API intermediate synthesis.

Synthesis

  • Route1

    References

    • BIOLIPOX AB Patent: WO2007/51982 A1, 2007 ; Location in patent: Page/Page column 49 ;
  • Route2
    • 2-(2,5-Dimethyl-1H-pyrrol-1-yl)-5-methoxypyridine|CS-0315723
      638352-78-0
    • ~99%
    • In-stock
      2-Amino-5-methoxypyridine|CS-D1544
      10167-97-2

    References

    • Tibotec Pharmaceuticals Ltd. Patent: WO2007/113290 A1, 2007 ; Location in patent: Page/Page column 40-42 ;
  • Route3
    • In-stock
      2-Amino-5-bromopyridine|CS-D1666
      1072-97-5
    • null|null
      124-41-4
    • ~44%
    • In-stock
      2-Amino-5-methoxypyridine|CS-D1544
      10167-97-2

    References

    • Van De Poel, Herve; Guillaumet, Gerald; Viaud-Massuard, Marie-Claude Heterocycles, 2002 , vol. 57, # 1 p. 55 - 71

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   0.6724
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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