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CS-W001157 4
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3-(Trifluoromethoxy)pyridin-2-amine

  • CAS No. 1206981-49-8

  • Cat. No. CS-W021783
  • Purity≥98%
  • MDL No.MFCD19690154

*For research and further manufacturing use only, not for direct human use.

3-(Trifluoromethoxy)pyridin-2-amine|CS-W021783

Structure of 1206981-49-8

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General Information

  • CAS No. 1206981-49-8
  • Cat. No. CS-W021783
  • Purity ≥98%
  • MDL No. MFCD19690154
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅F₃N₂O
  • Molecular Weight 178.11
  • Synonym(s) 3-Trifluoromethyoxy-pyridin-2-ylamine
  • SMILES NC1=NC=CC=C1OC(F)(F)F

Description

3-(Trifluoromethoxy)pyridin-2-amine features a trifluoromethoxy group at the 3-position and an amino substituent at the 2-position of the pyridine ring, creating a unique electron-deficient heteroaryl scaffold. This configuration enables direct coupling in cross-coupling reactions and facilitates incorporation into bioactive molecules. The compound exhibits enhanced metabolic stability and lipophilicity compared to non-fluorinated analogs, making it valuable for medicinal chemistry applications.

Application

3-(Trifluoromethoxy)pyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard coupling reactions. Its trifluoromethoxy group enhances metabolic stability and lipophilicity, while the pyridin-2-amine moiety facilitates direct functionalization or transition-metal-catalyzed transformations. The compound exhibits good bench stability and is compatible with common purification methods, making it well-suited for iterative synthesis workflows in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   1.5624
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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