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CS-W001157 4
Total: USD 88.00

5-Trifluoromethoxy-pyridin-2-ylamine

  • CAS No. 1221171-88-5

  • Cat. No. CS-W000469
  • Purity≥97%
  • MDL No.MFCD19690149

*For research and further manufacturing use only, not for direct human use.

5-Trifluoromethoxy-pyridin-2-ylamine|CS-W000469

Structure of 1221171-88-5

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General Information

  • CAS No. 1221171-88-5
  • Cat. No. CS-W000469
  • Purity ≥97%
  • MDL No. MFCD19690149
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅F₃N₂O
  • Molecular Weight 178.11
  • Synonym(s) 5-(Trifluoromethoxy)pyridin-2-amine
  • SMILES Nc1ccc(OC(F)(F)F)cn1

Description

5-Trifluoromethoxy-pyridin-2-ylamine features a trifluoromethoxy group at the 5-position and an amino substituent at the 2-position of a pyridine ring, creating a strongly electron-deficient heteroaromatic scaffold. This configuration enables direct incorporation into pharmaceutical intermediates, particularly those requiring enhanced metabolic stability and controlled electronic properties in kinase inhibitor scaffolds.

Application

5-Trifluoromethoxy-pyridin-2-ylamine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling reactions. Its trifluoromethoxy group enhances metabolic stability and modulates lipophilicity, while the primary amine facilitates further derivatization. The compound exhibits good bench stability and is compatible with common functional group transformations, making it well-suited for lead optimization and API development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   1.5624
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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