Lot numbers can be found on the outside label of a product:
5-Bromo-3-fluoropyridine-2-carbaldehyde
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CAS No. 669066-93-7
- Cat. No. CS-0047117
- Purity≥95%
- MDL No.None
*For research and further manufacturing use only, not for direct human use.
Structure of 669066-93-7
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General Information
- CAS No. 669066-93-7
- Cat. No. CS-0047117
- Purity ≥95%
- MDL No. None
- Storage -20°C, sealed storage, away from moisture
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₆H₃BrFNO
- Molecular Weight 204.00
- Synonym(s) 5-Bromo-3-fluoropyridine-2-carboxaldehyde
- SMILES O=CC1=C(C=C(C=N1)Br)F
Description
5-Bromo-3-fluoropyridine-2-carbaldehyde features a trifunctional pyridine core with bromo, fluoro, and aldehyde groups positioned for orthogonal reactivity. This electron-deficient scaffold enables direct coupling in cross-coupling and nucleophilic addition reactions, offering a robust platform for medicinal chemistry and agrochemical synthesis under standard conditions.
Application
5-Bromo-3-fluoropyridine-2-carbaldehyde serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The aldehyde group facilitates direct functionalization or oxime formation, while the fluorine and bromine substituents provide complementary sites for further diversification. Bench-stable and compatible with standard synthetic workflows, it functions effectively in the construction of complex heterocyclic scaffolds and API intermediates.
Synthesis
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Route1
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669066-92-6 - ~%
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In-stock
669066-93-7
References
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Kuduk, Scott D.; DiPardo, Robert M.; Chang, Ronald K.; Di Marco, Christina N.; Murphy, Kathy L.; Ransom, Richard W.; Reiss, Duane R.; Tang, Cuyue; Prueksaritanont, Thomayant; Pettibone, Douglas J.; Bock, Mark G. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3608 - 3612
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Route2
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In-stock
886373-28-0 - ~%
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In-stock
669066-93-7
References
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Sato Pharmaceutical Co., Ltd.; NAGAI Keita; NAGASAWA Koh; TAKAHASHI Hirobumi; BABA Motoaki; FUJIOKA Shinichi; KONDOH Eri; TANAKA Kenichi; ITOH Yoshiki Patent: EP2669270 A1, 2013 ; Location in patent: Paragraph 0950-0951 ;
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Route3
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669066-90-4 - ~%
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In-stock
669066-93-7
References
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Kuduk, Scott D.; DiPardo, Robert M.; Chang, Ronald K.; Di Marco, Christina N.; Murphy, Kathy L.; Ransom, Richard W.; Reiss, Duane R.; Tang, Cuyue; Prueksaritanont, Thomayant; Pettibone, Douglas J.; Bock, Mark G. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3608 - 3612
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302
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Precautionary Statements : P264-P270-P330-P501
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Quality Control
Computational Chemistry Data
- TPSA 29.96
- LogP 1.7957
- H_Acceptors 2
- H_Donors 0
- Rotatable_Bonds 1
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Key Words
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