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Propargyl-PEG2-CH2COOH

  • CAS No. 944561-46-0

  • Cat. No. CS-M3521
  • Molecule weight202.20
  • Purity≥95%
  • MDL No.MFCD30469071

*For research and further manufacturing use only, not for direct human use.

Propargyl-PEG2-CH2COOH|CS-M3521

Structure of 944561-46-0

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General Information

  • CAS No. 944561-46-0
  • Cat. No. CS-M3521
  • Purity ≥95%
  • MDL No. MFCD30469071
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₄O₅
  • Molecular Weight 202.20
  • Synonym(s) None
  • SMILES O=C(O)COCCOCCOCC#C

Description

Propargyl-PEG2-CH2COOH is a bifunctional linker featuring a terminal alkyne for copper-free click chemistry and a carboxylic acid handle for amide coupling. This water-soluble, bench-stable reagent enables efficient conjugation in bioorthogonal workflows, integrating seamlessly into peptide, protein, or oligonucleotide modifications with minimal side reactions.

Application

Propargyl-PEG2-CH2COOH serves as a versatile bifunctional linker for bioconjugation and polymer chemistry. The terminal alkyne enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC), while the carboxylic acid facilitates amide coupling or activation with common reagents. Its PEG2 spacer provides enhanced solubility and reduced aggregation, improving performance in aqueous environments. Ideal for synthesizing site-specific conjugates, peptide-PEG hybrids, and functionalized surfaces with minimal steric interference.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅲ
Hazard Statements : H315-H318-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   64.99
  • LogP   -0.246
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   9

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