Propargyl-PEG2-CH2COOH

Name: Propargyl-PEG2-CH2COOH
Brand: ChemScene
Availability: InStock
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CAS No. 944561-46-0
Cat. No. CS-M3521
Purity≥95%
MDL No.MFCD30469071

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

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Description

Propargyl-PEG2-CH2COOH is a bifunctional linker featuring a terminal alkyne for copper-free click chemistry and a carboxylic acid handle for amide coupling. This water-soluble, bench-stable reagent enables efficient conjugation in bioorthogonal workflows, integrating seamlessly into peptide, protein, or oligonucleotide modifications with minimal side reactions.

Application

Propargyl-PEG2-CH2COOH serves as a versatile bifunctional linker for bioconjugation and polymer chemistry. The terminal alkyne enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC), while the carboxylic acid facilitates amide coupling or activation with common reagents. Its PEG2 spacer provides enhanced solubility and reduced aggregation, improving performance in aqueous environments. Ideal for synthesizing site-specific conjugates, peptide-PEG hybrids, and functionalized surfaces with minimal steric interference.

General Information

CAS No. 944561-46-0
Cat. No. CS-M3521
Purity ≥95%
MDL No. MFCD30469071
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₁₄O₅
Molecular Weight 202.20
Synonym(s) None
SMILES O=C(O)COCCOCCOCC#C

Computational Chemistry Data

TPSA 64.99
LogP -0.246
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 9

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05,GHS07
Signal Word : Danger	UN#: 3265
Class : 8	Packing Group : Ⅲ
Hazard Statements : H315-H318-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group PEG

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Fatty chain compounds

Life Science Linker Other Linker

Life Science PROTAC PROTAC Linker

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Chemical Biology PEGylation Monofunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation Heterobifunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation PEG Oligomers

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

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Propargyl-PEG2-CH2COOH

CAS No. 944561-46-0

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