HOOCCH2O-PEG4-CH2COOH

Name: HOOCCH2O-PEG4-CH2COOH
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 77855-75-5
Cat. No. CS-0087653
Purity≥97%
MDL No.MFCD29079379

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 77855-75-5

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 77855-75-5
Cat. No. CS-0087653
Purity ≥97%
MDL No. MFCD29079379
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₂₂O₉
Molecular Weight 310.30
Synonym(s) None
SMILES O=C(O)COCCOCCOCCOCCOCC(O)=O

Description

This bifunctional PEG linker features carboxylic acid termini on both ends, enabling straightforward conjugation to amine-containing biomolecules or surfaces. The four-ethylene glycol repeat units provide enhanced solubility and reduced non-specific binding, making it ideal for bioconjugation applications in drug delivery and diagnostic development.

Application

HOOCCH₂O-PEG₄-CH₂COOH serves as a bifunctional, water-soluble linker ideal for conjugation and macrocyclic scaffold construction. The terminal carboxylic acid groups enable efficient amide coupling under standard conditions, while the polyether chain provides enhanced solubility and conformational flexibility. This structure facilitates reliable purification and stability in aqueous environments, making it well-suited for applications in peptide-drug conjugates, polymer chemistry, and bioconjugation workflows.

Synthesis

Route1
- 211746-78-0
- ~99%
- In-stock
  
  77855-75-5
References
- Wittmann, Valentin; Takayama, Shuichi; Gong, Ke Wei; Weitz-Schmidt, Gabriele; Wong, Chi-Huey Journal of Organic Chemistry, 1998 , vol. 63, # 15 p. 5137 - 5143
Route2
- 112-60-7
- ~%
- In-stock
  
  77855-75-5
References
- Wittmann, Valentin; Takayama, Shuichi; Gong, Ke Wei; Weitz-Schmidt, Gabriele; Wong, Chi-Huey Journal of Organic Chemistry, 1998 , vol. 63, # 15 p. 5137 - 5143

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 120.75
LogP -0.7614
H_Acceptors 7
H_Donors 2
Rotatable_Bonds 16

Other Classifications

Life Science PROTAC PROTAC Linker

Life Science Linker Bis-PEG-acid

Building Blocks Skeleton Fatty chain compounds

Building Blocks Functional Group PEG

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Chemical Biology PEGylation Monofunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation Heterobifunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation PEG Oligomers

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

Biochemistry Biochemicals and Reagents Bioconjugation PEGylation Reagents and PEG Spacers

Key Words

HOOCCH2O-PEG4-CH2COOH sigmaHOOCCH2O-PEG4-CH2COOH manufacturerHOOCCH2O-PEG4-CH2COOH priceHOOCCH2O-PEG4-CH2COOH structureHOOCCH2O-PEG4-CH2COOH SDSbuy HOOCCH2O-PEG4-CH2COOHHOOCCH2O-PEG4-CH2COOH supplierHOOCCH2O-PEG4-CH2COOH usesHOOCCH2O-PEG4-CH2COOH molecular weightprice of HOOCCH2O-PEG4-CH2COOHHOOCCH2O-PEG4-CH2COOH chemical name formula of HOOCCH2O-PEG4-CH2COOH

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

HOOCCH2O-PEG4-CH2COOH

CAS No. 77855-75-5

Recommended Products