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CS-W001157 4
Total: USD 88.00

2-Chloro-N-methylaniline

  • CAS No. 932-32-1

  • Cat. No. CS-0095956
  • Purity≥95%
  • MDL No.MFCD00045170

*For research and further manufacturing use only, not for direct human use.

2-Chloro-N-methylaniline|CS-0095956

Structure of 932-32-1

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General Information

  • CAS No. 932-32-1
  • Cat. No. CS-0095956
  • Purity ≥95%
  • MDL No. MFCD00045170
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈ClN
  • Molecular Weight 141.60
  • Synonym(s) 1-(2-chlorophenyl)-N-methylmethanamine
  • SMILES CNC1=CC=CC=C1Cl

Description

2-Chloro-N-methylaniline features a chlorinated aromatic ring paired with a methylaniline functionality, delivering enhanced reactivity in electrophilic substitution and improved solubility over unsubstituted aniline analogs. This bench-stable compound integrates readily into pharmaceutical intermediates and specialty dye synthesis.

Application

2-Chloro-N-methylaniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct functionalization at the aromatic ring due to its activated chlorine substituent. The N-methyl group enhances solubility and modulates electronic properties, while the compound exhibits excellent bench stability and compatibility with standard coupling reactions. It functions as a key intermediate in constructing heterocyclic scaffolds and bioactive molecules via palladium-catalyzed cross-coupling or nucleophilic substitution.

Synthesis

  • Route1
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      95-51-2
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      74-88-4
    • ~78%
    • In-stock
      2-Chloro-N-methylaniline|CS-0095956
      932-32-1

    References

    • Barluenga, Jose; Fananas, Francisco J.; Sanz, Roberto; Fernandez, Yolanda Chemistry - A European Journal, 2002 , vol. 8, # 9 p. 2034 - 2046
  • Route2
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      50-00-0
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      88-73-3
    • ~%
    • 2-Chloro-N,N-dimethylaniline|CS-0151312
      698-01-1
    • In-stock
      2-Chloro-N-methylaniline|CS-0095956
      932-32-1

    References

    • Catalysis Communications, , vol. 41, p. 115 - 118
  • Route3
    • null|null
      100-61-8
    • ~45%
    • In-stock
      4-Chloro-N-methylaniline|CS-W018297
      932-96-7
    • In-stock
      2-Chloro-N-methylaniline|CS-0095956
      932-32-1

    References

    • Synthetic Communications, , vol. 28, # 10 p. 1891 - 1896

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P305+P351+P338

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   2.3817
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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