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CS-W001157 4
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Propargyl-PEG3-alcohol

  • CAS No. 208827-90-1

  • Cat. No. CS-0019473
  • Purity≥95%
  • MDL No.MFCD13189984

*For research and further manufacturing use only, not for direct human use.

Propargyl-PEG3-alcohol|CS-0019473

Structure of 208827-90-1

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General Information

  • CAS No. 208827-90-1
  • Cat. No. CS-0019473
  • Purity ≥95%
  • MDL No. MFCD13189984
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₆O₄
  • Molecular Weight 188.22
  • Synonym(s) None
  • SMILES C#CCOCCOCCOCCO

Description

Propargyl-PEG3-alcohol offers a hydrophilic, linear PEG spacer with terminal alkyne and hydroxyl functionalities. This bifunctional scaffold enables site-specific conjugation via copper-catalyzed azide-alkyne cycloaddition while maintaining solubility in aqueous and organic media. Ideal for bioconjugation and polymer functionalization workflows.

Application

Propargyl-PEG3-alcohol serves as a versatile bifunctional linker for conjugation and polymer synthesis, combining the reactivity of a terminal alkyne with a hydrophilic PEG3 spacer and a primary alcohol. It enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) while offering improved solubility and reduced aggregation in aqueous environments. The pendant hydroxyl group facilitates further derivatization or immobilization, making it ideal for bioconjugation, surface functionalization, and modular synthesis of responsive materials.

Synthesis

  • Route1
    • null|null
      106-96-7
    • In-stock
      Triethylene glycol|CS-W018156
      112-27-6
    • ~73%
    • In-stock
      Propargyl-PEG3-alcohol|CS-0019473
      208827-90-1

    References

    • Wang, Tao; Ng, David Y. W.; Wu, Yuzhou; Thomas, Jessica; Tamtran, Thuy; Weil, Tanja Chemical Communications, 2014 , vol. 50, # 9 p. 1116 - 1118
  • Route2
    • In-stock
      Tos-PEG3|CS-0066341
      77544-68-4
    • null|null
      107-19-7
    • ~44%
    • In-stock
      Propargyl-PEG3-alcohol|CS-0019473
      208827-90-1

    References

    • Baccaro, Anna; Weisbrod, Samuel H.; Marx, Andreas Synthesis, 2007 , # 13 p. 1949 - 1954
  • Route3

    References

    • Gavrilyuk, Julia I.; Wuellner, Ulrich; Barbas III, Carlos F. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 5 p. 1421 - 1424

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   47.92
  • LogP   -0.3383
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   9

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