Propargyl-PEG3-methane

Name: Propargyl-PEG3-methane
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 89635-82-5
Cat. No. CS-0114431
Purity≥97%
MDL No.MFCD27977518

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 89635-82-5
Cat. No. CS-0114431
Purity ≥97%
MDL No. MFCD27977518
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₈O₄
Molecular Weight 202.25
Synonym(s) None
SMILES COCCOCCOCCOCC#C

Description

Propargyl-PEG3-methane delivers a hydrophilic, three-ethylene glycol unit spacer flanked by a terminal alkyne for bioorthogonal conjugation. This bench-stable, moisture-tolerant linker integrates seamlessly into probe design, enabling efficient copper-free click reactions with azide-functionalized biomolecules.

Application

Propargyl-PEG3-methane serves as a versatile, bench-stable linker for bioconjugation and modular synthesis. Its terminal alkyne enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC), while the PEG3 spacer provides solubility and reduced aggregation. Functions reliably in peptide labeling, probe conjugation, and polymer functionalization with high yield and minimal side reactions.

Synthesis

Route1
- In-stock
  
  112-35-6
- 106-96-7
- ~91%
- In-stock
  
  89635-82-5
References
- Jervis, Peter J.; Moulis, Marie; Jukes, John-Paul; Ghadbane, Hemza; Cox, Liam R.; Cerundolo, Vincenzo; Besra, Gurdyal S. Carbohydrate Research, 2012 , vol. 356, p. 152 - 162

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 36.92
LogP 0.3158
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 10

Other Classifications

Building Blocks Functional Group PEG

Building Blocks Skeleton Fatty chain compounds

Life Science Linker Alkyne PEG

Life Science Linker m-PEG

Life Science Linker Propargyl PEG

Life Science Click Chemistry Reagents

Chemical Biology Pharmaceutical Development and Drug Discovery Research Conjugation Chemistry/Click Chemistry PEG Azides/Alkynes

Chemical Biology Conjugation Chemistry/Click Chemistry PEG Azides/Alkynes

Chemical Biology PEGylation mPEG (Methyl Polyethylene Glycols)

Chemical Biology PEGylation Monofunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation Heterobifunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Bioconjugation PEGylation Reagents and PEG Spacers

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Propargyl-PEG3-methane

CAS No. 89635-82-5

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