tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate

Name: tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate
Brand: ChemScene
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CAS No. 170911-92-9
Cat. No. CS-W005015
Purity≥97%
MDL No.MFCD04115065

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Excepted Quantity	$0.00
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tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate|CS-W005015

Structure of 170911-92-9

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General Information

CAS No. 170911-92-9
Cat. No. CS-W005015
Purity ≥97%
MDL No. MFCD04115065
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₅H₂₃N₃O₂
Molecular Weight 277.36
Synonym(s) 4-(4-Boc-piperazin-1-yl)aniline
SMILES C(C)(C)(C)OC(=O)N1CCN(CC1)C2=CC=C(C=C2)N

Description

tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate features a piperazine core linked to a para-aminophenyl group, delivering a robust scaffold for medicinal chemistry. The tert-butyl ester moiety enhances solubility and stability while enabling straightforward deprotection under mild acidic conditions. This compound serves as a key intermediate in the synthesis of bioactive molecules, particularly those targeting CNS disorders and kinase pathways.

Application

tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate serves as a versatile building block for the synthesis of biologically active piperazine-based compounds. Its robust tert-butoxycarbonyl (Boc) group offers excellent bench stability and facilitates straightforward deprotection under mild acidic conditions. The pendant aniline functionality enables direct coupling reactions, including Suzuki-Miyaura, Ullmann, and reductive amination, making it ideal for constructing diverse heterocyclic scaffolds and drug candidates in medicinal chemistry workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 58.8
LogP 2.3259
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate

CAS No. 170911-92-9

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