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CS-W001157 4
Total: USD 88.00

4-(Piperazin-1-yl)aniline

  • CAS No. 67455-41-8

  • Cat. No. CS-0128861
  • Purity≥97%
  • MDL No.MFCD01365906

*For research and further manufacturing use only, not for direct human use.

4-(Piperazin-1-yl)aniline|CS-0128861

Structure of 67455-41-8

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General Information

  • CAS No. 67455-41-8
  • Cat. No. CS-0128861
  • Purity ≥97%
  • MDL No. MFCD01365906
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₅N₃
  • Molecular Weight 177.25
  • Synonym(s) 1-(4-Aminophenyl)piperazine
  • SMILES NC1=CC=C(N2CCNCC2)C=C1

Description

4-(Piperazin-1-yl)aniline features a piperazine ring appended to an aniline scaffold, delivering enhanced solubility and tunable basicity. This hybrid moiety integrates readily into medicinal chemistry scaffolds, where the electron-rich piperazine enhances target engagement while the aromatic amine enables further derivatization.

Application

4-(Piperazin-1-yl)aniline serves as a versatile bifunctional building block in medicinal chemistry, enabling efficient access to diverse heterocyclic scaffolds. Its piperazine moiety provides enhanced solubility and hydrogen-bonding capacity, while the aniline group facilitates coupling reactions and further functionalization. The compound exhibits good bench stability and is readily purified by standard techniques, making it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1

    References

    • Yadav, Veena; Gupta, Shweta; Kumar, Rupesh; Singh, Gajendra; Lagarkha, Rekha Synthetic Communications, 2012 , vol. 42, # 2 p. 213 - 222
  • Route2
    • null|null
      100-25-4
    • ~%
    • In-stock
      4-(Piperazin-1-yl)aniline|CS-0128861
      67455-41-8

    References

    • Tetrahedron Letters, , vol. 40, # 31 p. 5655 - 5659
  • Route3
    • null|null
      100-00-5
    • ~%
    • In-stock
      4-(Piperazin-1-yl)aniline|CS-0128861
      67455-41-8

    References

    • Tetrahedron Letters, , vol. 40, # 31 p. 5655 - 5659

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   41.29
  • LogP   0.6784
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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