5-Chloro-2-methoxybenzenesulfonyl chloride

Name: 5-Chloro-2-methoxybenzenesulfonyl chloride
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 22952-32-5
Cat. No. CS-W012798
Purity≥97%
MDL No.MFCD00052959

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Chloro-2-methoxybenzenesulfonyl chloride|CS-W012798

Structure of 22952-32-5

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 22952-32-5
Cat. No. CS-W012798
Purity ≥97%
MDL No. MFCD00052959
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₆Cl₂O₃S
Molecular Weight 241.08
Synonym(s) 5-chloro-2-methoxybenzene-1-sulfonyl chloride
SMILES O=S(C1=CC(Cl)=CC=C1OC)(Cl)=O

Description

5-Chloro-2-methoxybenzenesulfonyl chloride features a sulfonyl chloride group flanked by electron-withdrawing chlorine and electron-donating methoxy substituents, enabling selective electrophilic functionalization. This balance enhances reactivity in amide and sulfonamide synthesis while maintaining stability under standard bench conditions.

Application

5-Chloro-2-methoxybenzenesulfonyl chloride serves as a versatile sulfonylating agent for the efficient introduction of a sulfonamide moiety in medicinal chemistry and agrochemical synthesis. Its ortho-methoxy and meta-chloro substituents enhance reactivity while maintaining bench stability, enabling clean transformations with amines and alcohols under mild conditions. The compound exhibits excellent functional group tolerance and facilitates straightforward purification, making it ideal for building complex heterocyclic scaffolds and targeted API intermediates.

Synthesis

Route1
- 623-12-1
- ~76%
- In-stock
  
  22952-32-5
References
- Guo, Cheng; Qiu, Jun; Zhang, Xumu; Verdugo, Dawn; Larter, Martin L.; Christie, Ray; Kenney, Patrick; Walsh, Patrick J. Tetrahedron, 1997 , vol. 53, # 12 p. 4145 - 4158
Route2
- 106-48-9
- ~%
- In-stock
  
  22952-32-5
References
- Tetrahedron, , vol. 53, # 12 p. 4145 - 4158
Route3
- 46170-99-4
- ~%
- In-stock
  
  22952-32-5
References
- Journal of the Chemical Society, , vol. 127, p. 2746

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3261
Class : 8	Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 43.37
LogP 2.2761
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

22952-32-5 sigma22952-32-5 manufacturer22952-32-5 price22952-32-5 structure22952-32-5 SDSbuy 22952-32-522952-32-5 supplier22952-32-5 uses22952-32-5 molecular weightprice of 22952-32-522952-32-5 chemical name formula of 22952-32-5

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

5-Chloro-2-methoxybenzenesulfonyl chloride

CAS No. 22952-32-5

Recommended Products

General Information

Description

Application

Synthesis

References

References

References

Safety Information

Quality Control

Computational Chemistry Data

Similar Products

Other Classifications

Recently Viewed Products

Key Words