2,3-Dihydro-benzo[1,4]dioxine-6-sulfonyl chloride

Name: 2,3-Dihydro-benzo[1,4]dioxine-6-sulfonyl chloride
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 63758-12-3
Cat. No. CS-0071523
Purity≥95%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2,3-Dihydro-benzo[1,4]dioxine-6-sulfonyl chloride|CS-0071523

Structure of 63758-12-3

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 63758-12-3
Cat. No. CS-0071523
Purity ≥95%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₇ClO₄S
Molecular Weight 234.66
Synonym(s) 2,3-Dihydro-1,4-benzodioxine-6-sulfonyl chloride
SMILES O=S(C1=CC(OCCO2)=C2C=C1)(Cl)=O

Description

2,3-Dihydro-benzo[1,4]dioxine-6-sulfonyl chloride features a reactive sulfonyl chloride group attached to a stable dihydrobenzodioxine scaffold. This configuration enables selective coupling in synthetic routes requiring sulfonamide formation under mild conditions. The molecule exhibits enhanced solubility in polar organic solvents and demonstrates robust stability during handling, facilitating integration into complex molecular architectures.

Application

2,3-Dihydro-benzo[1,4]dioxine-6-sulfonyl chloride serves as a versatile sulfonylating agent for the introduction of sulfonate groups into diverse substrates. Its benzo[1,4]dioxine core provides structural rigidity and metabolic stability, while the reactive sulfonyl chloride moiety enables efficient coupling with amines, alcohols, and thiols under mild conditions. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for use in medicinal chemistry and process development workflows requiring selective sulfonation.

Synthesis

Route1
- 274-09-9
- 107-06-2
- ~96%
- In-stock
  
  63758-12-3
References
- Eli Lilly and Company Patent: US5387681 A1, 1995 ;
Route2
- In-stock
  
  493-09-4
- ~%
- In-stock
  
  63758-12-3
References
- Recueil des Travaux Chimiques des Pays-Bas, , vol. 76, p. 129,138,145

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3261
Class : 8	Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 52.6
LogP 1.3853
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Benzodioxane compounds

Key Words

63758-12-3 sigma63758-12-3 manufacturer63758-12-3 price63758-12-3 structure63758-12-3 SDSbuy 63758-12-363758-12-3 supplier63758-12-3 uses63758-12-3 molecular weightprice of 63758-12-363758-12-3 chemical name formula of 63758-12-3

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

2,3-Dihydro-benzo[1,4]dioxine-6-sulfonyl chloride

CAS No. 63758-12-3

Recommended Products