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CS-W001157 4
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4-Cyclohexylbenzene-1-sulfonyl chloride

  • CAS No. 56354-57-5

  • Cat. No. CS-0068013
  • Purity≥95%
  • MDL No.MFCD00625713

*For research and further manufacturing use only, not for direct human use.

4-Cyclohexylbenzene-1-sulfonyl chloride|CS-0068013

Structure of 56354-57-5

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General Information

  • CAS No. 56354-57-5
  • Cat. No. CS-0068013
  • Purity ≥95%
  • MDL No. MFCD00625713
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₅ClO₂S
  • Molecular Weight 258.76
  • Synonym(s) 4-Cyclohexylbenzenesulfonyl chloride
  • SMILES O=S(C1=CC=C(C2CCCCC2)C=C1)(Cl)=O

Description

4-Cyclohexylbenzene-1-sulfonyl chloride features a robust sulfonyl chloride group attached to a cyclohexyl-substituted aromatic ring, enabling efficient coupling in amide and sulfonamide synthesis. This bench-stable reagent integrates readily into complex molecular architectures under mild conditions, offering high reactivity with nucleophiles while maintaining compatibility with diverse functional groups.

Application

4-Cyclohexylbenzene-1-sulfonyl chloride serves as a versatile sulfonylating agent for the efficient introduction of a bulky, hydrophobic sulfonyl group into organic frameworks. Its stability under standard bench conditions and compatibility with diverse nucleophiles—particularly amines and alcohols—facilitates straightforward synthesis of sulfonamide and sulfonate derivatives. The cyclohexyl moiety enhances lipophilicity and steric bulk, making it valuable in medicinal chemistry applications requiring modulated solubility and metabolic stability.

Synthesis

  • Route1

    References

    • Journal of the American Chemical Society, , vol. 63, p. 3446

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314-H318
Precautionary Statements : P280-P301+P330+P331-P302+P352-P304+P340

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Computational Chemistry Data

  • TPSA   34.14
  • LogP   3.6618
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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