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CS-W001157 4
Total: USD 88.00

Propynyl-PEG1-Ac

  • CAS No. 944561-45-9

  • Cat. No. CS-0147784
  • Molecule weight158.15
  • Purity≥95%
  • MDL No.MFCD30469070

*For research and further manufacturing use only, not for direct human use.

Propynyl-PEG1-Ac|CS-0147784

Structure of 944561-45-9

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General Information

  • CAS No. 944561-45-9
  • Cat. No. CS-0147784
  • Purity ≥95%
  • MDL No. MFCD30469070
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀O₄
  • Molecular Weight 158.15
  • Synonym(s) None
  • SMILES O=C(O)COCCOCC#C

Description

Propynyl-PEG1-Ac features a reactive terminal alkyne paired with a short, hydrophilic PEG spacer and acetyl protection. This combination enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) while maintaining solubility in aqueous and organic media. The acetyl group stabilizes the propynyl moiety against premature reaction, offering controlled bioconjugation under standard conditions.

Application

Propynyl-PEG1-Ac enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation and polymer functionalization. Its terminal alkyne group exhibits excellent stability, compatibility with diverse functional groups, and facilitates straightforward purification via standard chromatographic methods. This reagent serves as a versatile building block for constructing well-defined PEGylated architectures in drug delivery and materials science applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H315-H318-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   55.76
  • LogP   -0.2626
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   6

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