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CS-W001157 4
Total: USD 88.00

Boc-Phe-Gly-OH

  • CAS No. 25616-33-5

  • Cat. No. CS-0101219
  • Purity≥95%
  • MDL No.MFCD00134859

*For research and further manufacturing use only, not for direct human use.

Boc-Phe-Gly-OH|CS-0101219

Structure of 25616-33-5

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General Information

  • CAS No. 25616-33-5
  • Cat. No. CS-0101219
  • Purity ≥95%
  • MDL No. MFCD00134859
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₂₂N₂O₅
  • Molecular Weight 322.36
  • Synonym(s) None
  • SMILES O=C(O)CNC([C@H](CC1=CC=CC=C1)NC(OC(C)(C)C)=O)=O

Description

Boc-Phe-Gly-OH serves as a protected dipeptide building block for peptide synthesis, featuring a tert-butoxycarbonyl group at the N-terminus and a free C-terminal carboxylate. This configuration enables direct coupling in solid-phase and solution-phase protocols without additional protection steps. The phenylalanine residue provides aromatic stability, while the glycine linker ensures conformational flexibility.

Application

Boc-Phe-Gly-OH serves as a reliable dipeptide building block for solid-phase peptide synthesis, offering enhanced stability and ease of handling. The Boc group provides orthogonal protection for the α-amino function, enabling selective deprotection under mild acidic conditions. Its well-documented compatibility with standard coupling protocols facilitates efficient chain elongation, while the C-terminal carboxylic acid supports direct activation or esterification in peptide assembly workflows.

Synthesis

  • Route1
    • null|null
      42280-29-5
    • ~91%
    • In-stock
      Boc-Phe-Gly-OH|CS-0101219
      25616-33-5

    References

    • Salvadori, Severo; Marastoni, Mauro; Balboni, Gianfranco; Sarto, Gian Pietro; Tomatis, Roberto Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 889 - 894
  • Route2

    References

    • Zhang, Jian; Li, Xiaoyang; Jiang, Yuqi; Feng, Jinhong; Li, Xiaoguang; Zhang, Yingjie; Xu, Wenfang Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 11 p. 3055 - 3064
  • Route3
    • null|null
      78569-23-0
    • Glycine, 99%|CS-1269057
      56-40-6
    • ~92%
    • In-stock
      Boc-Phe-Gly-OH|CS-0101219
      25616-33-5

    References

    • Nagao, Yoshimitsu; Miyasaka, Tadayo; Seno, Kaoru; Fujita, Eiichi; Shibata, Daisuke; Doi, Etsushiro Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2439 - 2446

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H317
Precautionary Statements : P261-P272-P280-P302+P352-P363-P501

Quality Control

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Computational Chemistry Data

  • TPSA   104.73
  • LogP   1.3232
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   6

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