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CS-W001157 4
Total: USD 88.00

Propargyl-PEG2-OH

  • CAS No. 7218-43-1

  • Cat. No. CS-0108947
  • Purity≥95%
  • MDL No.MFCD00053353

*For research and further manufacturing use only, not for direct human use.

Propargyl-PEG2-OH|CS-0108947

Structure of 7218-43-1

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General Information

  • CAS No. 7218-43-1
  • Cat. No. CS-0108947
  • Purity ≥95%
  • MDL No. MFCD00053353
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₂O₃
  • Molecular Weight 144.17
  • Synonym(s) None
  • SMILES C#CCOCCOCCO

Description

Propargyl-PEG2-OH is a bifunctional linker featuring a terminal alkyne for click chemistry and a hydroxyl end group for derivatization. This water-soluble, bench-stable reagent facilitates efficient conjugation in bioorthogonal reactions, enabling site-specific labeling of proteins, nucleic acids, and synthetic polymers under mild conditions.

Application

Propargyl-PEG2-OH serves as a versatile bifunctional linker for conjugation and polymer synthesis, combining the reactivity of a terminal alkyne with a hydrophilic PEG2 spacer. It facilitates efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) while maintaining solubility and stability in aqueous and organic media. Ideal for site-specific labeling, bioconjugation, and functionalizing nanoparticles or peptides, it enables straightforward purification and high-yielding reactions under mild conditions.

Synthesis

  • Route1
    • null|null
      106-96-7
    • In-stock
      Diethylene glycol|CS-0014055
      111-46-6
    • ~94%
    • In-stock
      Propargyl-PEG2-OH|CS-0108947
      7218-43-1

    References

    • Percec, Virgil; Leowanawat, Pawaret; Sun, Hao-Jan; Kulikov, Oleg; Nusbaum, Christopher D.; Tran, Tam M.; Bertin, Annabelle; Wilson, Daniela A.; Peterca, Mihai; Zhang, Shaodong; Kamat, Neha P.; Vargo, Kevin; Moock, Diana; Johnston, Eric D.; Hammer, Daniel A.; Pochan, Darrin J.; Chen, Yingchao; Chabre, Yoann M.; Shiao, Tze C.; Bergeron-Brlek, Milan; Andre, Sabine; Roy, Rene; Gabius, Hans-J.; Heiney, Paul A. Journal of the American Chemical Society, 2013 , vol. 135, # 24 p. 9055 - 9077
  • Route2
    • null|null
      6188-74-5
    • ~%
    • In-stock
      Propargyl-PEG2-OH|CS-0108947
      7218-43-1

    References

    • Atavin,A.S. et al. Journal of Organic Chemistry USSR (English Translation), 1967 , vol. 3, p. 10 - 12 Zhurnal Organicheskoi Khimii, 1967 , vol. 3, # 1 p. 12 - 15
  • Route3
    • null|null
      75-21-8
    • null|null
      107-19-7
    • ~%
    • In-stock
      Propargyl-PEG2-OH|CS-0108947
      7218-43-1

    References

    • Reppe et al. Justus Liebigs Annalen der Chemie, 1955 , vol. 596, p. 65

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H315-H319
Precautionary Statements : P264-P280-P302+P352-P362-P370+P378-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.69
  • LogP   -0.3549
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   6

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