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2-Hydroxyethyl benzoate

  • CAS No. 94-33-7

  • Cat. No. CS-0233065
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Hydroxyethyl benzoate|CS-0233065

Structure of 94-33-7

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General Information

  • CAS No. 94-33-7
  • Cat. No. CS-0233065
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀O₃
  • Molecular Weight 166.17
  • Synonym(s) 2-Hydroxyethyl Benzoate (Ethylene Glycol Monobenzoate)
  • SMILES C1=CC=C(C=C1)C(=O)OCCO

Description

2-Hydroxyethyl benzoate is a bench-stable ester featuring a phenolic hydroxyl group and a terminal ethylene glycol moiety. This dual functionality enables seamless integration into polymer architectures and bioconjugation workflows. The molecule's balanced solubility profile supports use in both aqueous and organic media, facilitating applications in drug delivery systems and surface modification technologies.

Application

2-Hydroxyethyl benzoate serves as a stable, bench-ready ester intermediate for the synthesis of bioactive molecules and functional polymers. Its hydroxyl and ester functionalities enable orthogonal reactivity in coupling and protection strategies, facilitating efficient derivatization in medicinal chemistry and materials science applications.

Synthesis

  • Route1

    References

    • Maki, Toshihide; Iwasaki, Fumiaki; Matsumura, Yoshihiro Tetrahedron Letters, 1998 , vol. 39, # 31 p. 5601 - 5604
  • Route2

    References

    • Gonsalvi, Luca; Arends, Isabel W. C. E.; Moilanen, Pasi; Sheldon, Roger A. Advanced Synthesis and Catalysis, 2003 , vol. 345, # 12 p. 1321 - 1328
  • Route3

    References

    • MEDICONTUR ORVOSTECHNIKAI KFT.; NAGY, Jozsef; AGOSTON, Peter; PUSZTAI, Erika; TURKEVI-NAGY, Nandor Patent: WO2012/10918 A2, 2012 ; Location in patent: Page/Page column 11 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   0.8357
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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