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CS-W001157 4
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4-((2-Hydroxyethoxy)carbonyl)benzoic acid

  • CAS No. 1137-99-1

  • Cat. No. CS-0186853
  • Purity≥95%
  • MDL No.MFCD20259688

*For research and further manufacturing use only, not for direct human use.

4-((2-Hydroxyethoxy)carbonyl)benzoic acid|CS-0186853

Structure of 1137-99-1

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General Information

  • CAS No. 1137-99-1
  • Cat. No. CS-0186853
  • Purity ≥95%
  • MDL No. MFCD20259688
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₀O₅
  • Molecular Weight 210.18
  • Synonym(s) Terephthalic acid, monohydroxyethyl ester sodium salts Terephthalic acid,monohydroxyethyl ester sodium salts
  • SMILES O=C(O)C1=CC=C(C(OCCO)=O)C=C1

Description

4-((2-Hydroxyethoxy)carbonyl)benzoic acid features a hydrophilic ethylene glycol linker attached to a benzoic acid scaffold, enabling enhanced aqueous solubility and facilitating conjugation in bioconjugation workflows. The pendant hydroxyl group offers additional functional handles for derivatization, while the carboxylic acid provides a robust anchor for coupling reactions under standard conditions.

Application

4-((2-Hydroxyethoxy)carbonyl)benzoic acid serves as a versatile bifunctional building block, enabling facile conjugation via its carboxylic acid and pendant hydroxyl groups. The hydroxyethyl ester functionality enhances solubility and facilitates downstream derivatization, while the aromatic core provides structural rigidity. This compound demonstrates excellent bench stability and compatibility with standard peptide coupling and esterification protocols, making it well-suited for use in medicinal chemistry and materials synthesis.

Synthesis

  • Route1
    • Bis(β-hydroxyethyl) terephthalate|CS-0040083
      959-26-2
    • ~%
    • In-stock
      4-((2-Hydroxyethoxy)carbonyl)benzoic acid|CS-0186853
      1137-99-1

    References

    • Zahn; Krzikalla Makromolekulare Chemie, 1957 , vol. 23, p. 31,51 Angewandte Chemie, 1955 , vol. 67, p. 108
  • Route2
    • null|null
      97794-78-0
    • ~%
    • In-stock
      4-((2-Hydroxyethoxy)carbonyl)benzoic acid|CS-0186853
      1137-99-1

    References

    • Zahn et al. Angewandte Chemie, 1956 , vol. 68, p. 229,233
  • Route3

    References

    • Zahn; Krzikalla Makromolekulare Chemie, 1957 , vol. 23, p. 31,51 Angewandte Chemie, 1955 , vol. 67, p. 108

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   83.83
  • LogP   0.5339
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   4

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