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CS-W001157 4
Total: USD 88.00

2-Hydroxyethyl acetate

  • CAS No. 542-59-6

  • Cat. No. CS-0154995
  • Purity≥60%
  • MDL No.MFCD00002864

*For research and further manufacturing use only, not for direct human use.

2-Hydroxyethyl acetate|CS-0154995

Structure of 542-59-6

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General Information

  • CAS No. 542-59-6
  • Cat. No. CS-0154995
  • Purity ≥60%
  • MDL No. MFCD00002864
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₈O₃
  • Molecular Weight 104.10
  • Synonym(s) Glycol monoacetate; 2-Hydroxyethyl acetate
  • SMILES CC(=O)OCCO

Description

2-Hydroxyethyl acetate is a bench-stable, moisture-tolerant ester featuring a hydroxyl group and acetyl moiety. This bifunctional structure enables seamless integration into synthetic workflows requiring both polarity modulation and reactive handles. The molecule pairs effectively in coupling reactions and serves as a protective group for diols or as a solubilizing agent in organic synthesis.

Application

2-Hydroxyethyl acetate serves as a versatile acetylating agent and protecting group for alcohols, enabling selective O-acetylation under mild conditions. Its bench-stable nature and ease of purification make it ideal for use in multi-step syntheses, particularly in carbohydrate chemistry and peptide derivatization. The molecule functions effectively as a masked acetic acid equivalent and is compatible with a range of functional groups, facilitating efficient synthetic workflows in medicinal and process chemistry applications.

Synthesis

  • Route1
    • In-stock
      Ethylene glycol,98%|CS-0015059
      107-21-1
    • null|null
      64-19-7
    • ~92%
    • In-stock
      2-Hydroxyethyl acetate|CS-0154995
      542-59-6

    References

    • Srinivas; Mahender; Das, Biswanath Synlett, 2003 , # 15 p. 2419 - 2421
  • Route2

    References

    • Spaggiari, Alberto; Blaszczak, Larry C.; Prati, Fabio Organic Letters, 2004 , vol. 6, # 22 p. 3885 - 3888
  • Route3
    • N-Cyclohexylacetamide|CS-0162808
      1124-53-4
    • In-stock
      Ethylene glycol,98%|CS-0015059
      107-21-1
    • ~0%
    • In-stock
      2-Hydroxyethyl acetate|CS-0154995
      542-59-6
    • null|null
      108-91-8

    References

    • Spaggiari, Alberto; Blaszczak, Larry C.; Prati, Fabio Organic Letters, 2004 , vol. 6, # 22 p. 3885 - 3888

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H318
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   -0.4582
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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