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CS-W001157 4
Total: USD 88.00

2-(Ethoxycarbonyl)thiazole-4-carboxylic acid

  • CAS No. 911466-96-1

  • Cat. No. CS-W019091
  • Purity≥97%
  • MDL No.MFCD11110995
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

2-(Ethoxycarbonyl)thiazole-4-carboxylic acid|CS-W019091

Structure of 911466-96-1

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Description

2-(Ethoxycarbonyl)thiazole-4-carboxylic acid features a thiazole scaffold bearing both ethoxycarbonyl and carboxylic acid functionalities, enabling direct integration into heterocyclic synthesis. The electron-deficient ring facilitates nucleophilic substitution, while the orthogonal polar groups support conjugation in bioactive molecule design. This bench-stable reagent streamlines access to functionalized thiazoles under standard conditions.

Application

2-(Ethoxycarbonyl)thiazole-4-carboxylic acid serves as a versatile building block for heterocyclic synthesis, enabling efficient access to thiazole-based scaffolds through standard amidation, esterification, and decarboxylation protocols. Its dual electrophilic (carboxylate and carbonyl) functionalities tolerate diverse reaction conditions and facilitate downstream derivatization in medicinal chemistry workflows. The ethoxycarbonyl group enhances solubility and simplifies purification, while the intact thiazole ring ensures structural stability under common bench-scale transformations.

General Information

  • CAS No. 911466-96-1
  • Cat. No. CS-W019091
  • Purity ≥97%
  • MDL No. MFCD11110995
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO₄S
  • Molecular Weight 201.20
  • Synonym(s) 2,4-Thiazoledicarboxylic acid,2-ethyl ester
  • SMILES O=C(C1=CSC(C(OCC)=O)=N1)O

Computational Chemistry Data

  • TPSA   76.49
  • LogP   1.018
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   3

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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