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Structure of 33097-11-9
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4,6-Dichloro-2-(methylthio)pyrimidine-5-carbaldehyde features a pyrimidine core functionalized with two chlorine atoms at C4 and C6, a methylthio group at C2, and a formyl substituent at C5. This electron-deficient heterocycle serves as a key building block in medicinal chemistry, enabling direct coupling in cross-coupling reactions and facilitating the synthesis of advanced pharmaceutical intermediates under standard conditions.
4,6-Dichloro-2-(methylthio)pyrimidine-5-carbaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. Its dual chloro substituents facilitate nucleophilic aromatic substitution, while the aldehyde group supports imine formation and reductive amination. The methylthio group provides orthogonal functionalization potential, enhancing synthetic flexibility for targeted compound libraries. Bench-stable and compatible with standard purification methods, it functions effectively in multi-step syntheses requiring precise regiocontrol and functional group tolerance.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: