2-Bromo-4-fluorophenol

Name: 2-Bromo-4-fluorophenol
Brand: ChemScene
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CAS No. 496-69-5
Cat. No. CS-W003971
Purity≥95%
MDL No.MFCD00010614

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 496-69-5
Cat. No. CS-W003971
Purity ≥95%
MDL No. MFCD00010614
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₄BrFO
Molecular Weight 191.00
Synonym(s) None
SMILES FC1=CC=C(C(Br)=C1)O

Description

2-Bromo-4-fluorophenol features a phenolic hydroxyl group flanked by bromine and fluorine substituents, creating a uniquely reactive platform for cross-coupling and electrophilic functionalization. This electron-deficient aryl scaffold enables selective transformations under mild conditions, delivering high yields in Suzuki-Miyaura and Buchwald-Hartwig reactions. The molecule exhibits excellent stability during storage and handling, making it a reliable intermediate for pharmaceutical and agrochemical synthesis.

Application

2-Bromo-4-fluorophenol serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient Suzuki-Miyaura and Stille couplings due to its well-defined halogen reactivity. The bromo group facilitates palladium-catalyzed cross-coupling, while the fluorine enhances metabolic stability and modulates electronic properties. Its bench-stable crystalline form simplifies handling and purification, making it ideal for multi-step synthetic sequences requiring functional group tolerance and predictable regiochemistry.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 20.23
LogP 2.2938
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Bioactive Molecules Dye and Bio-assay Reagents

Building Blocks Functional Group Phenol

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2-Bromo-4-fluorophenol

CAS No. 496-69-5

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