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CS-W001157 4
Total: USD 88.00

1-(4-Bromophenyl)ethylamine

  • CAS No. 24358-62-1

  • Cat. No. CS-W019475
  • Purity≥96%
  • MDL No.MFCD00025548

*For research and further manufacturing use only, not for direct human use.

1-(4-Bromophenyl)ethylamine|CS-W019475

Structure of 24358-62-1

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General Information

  • CAS No. 24358-62-1
  • Cat. No. CS-W019475
  • Purity ≥96%
  • MDL No. MFCD00025548
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀BrN
  • Molecular Weight 200.08
  • Synonym(s) p-Bromo-α-phenylethylamine
  • SMILES NC(C1=CC=C(Br)C=C1)C

Description

1-(4-Bromophenyl)ethylamine is a bench-stable arylalkyl amine featuring a para-brominated phenyl ring and a chiral ethylamine side chain. This structure enables direct incorporation into pharmaceutical intermediates, offering enhanced solubility and reactivity in transition metal-catalyzed coupling processes. The bromo group serves as a key handle for downstream functionalization.

Application

1-(4-Bromophenyl)ethylamine serves as a versatile building block for the synthesis of pharmaceutically relevant arylalkylamines. Its brominated aromatic moiety enables subsequent cross-coupling reactions, while the primary amine facilitates derivatization via acylation, alkylation, or reductive amination. The compound exhibits good bench stability and ease of purification, making it suitable for iterative synthesis workflows in medicinal chemistry and process development.

Synthesis

  • Route1

    References

    • Talwar, Dinesh; Salguero, Noemi Poyatos; Robertson, Craig M.; Xiao, Jianliang Chemistry - A European Journal, 2014 , vol. 20, # 1 p. 245 - 252
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    • In-stock
      1-(4-Bromophenyl)ethylamine|CS-W019475
      24358-62-1

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 14 p. 3894 - 3899
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      59862-55-4
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    • In-stock
      1-(4-Bromophenyl)ethylamine|CS-W019475
      24358-62-1

    References

    • Journal of the American Chemical Society, , vol. 74, p. 5185 Journal of Organic Chemistry, , vol. 20, p. 1757,1758,1759

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314-H318
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.4688
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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