Lot numbers can be found on the outside label of a product:
Methanesulfonamide
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CAS No. 3144-09-0
- Cat. No. CS-W020062
- Purity≥98%
- MDL No.MFCD00007940
*For research and further manufacturing use only, not for direct human use.
Structure of 3144-09-0
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General Information
- CAS No. 3144-09-0
- Cat. No. CS-W020062
- Purity ≥98%
- MDL No. MFCD00007940
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula CH₅NO₂S
- Molecular Weight 95.12
- Synonym(s) None
- SMILES CS(=O)(N)=O
Description
Methanesulfonamide is used in the synthesis of important organic reagents such as N-(2-methylthio-1-p-toluenesufonyl)methanesulfonamide and tert-butyl ((2-(trimethylsilyl)ethyl)sulfonyl)carbamate.It can be used as a source of nitrogen in the conversion of carboxylic acids to corresponding nitriles.It is widely used as a reagent in the synthesis of medicinally important compounds such as derivatives of indole-N-acetamide, methanesulfonamide pyrimidine-substituted 3,5-dihydroxy-6-heptenoates and repertaxin.
Application
Methanesulfonamide serves as a stable, bench-ready sulfonamide source for amine incorporation in medicinal chemistry and process synthesis. Its high functional group tolerance enables direct use in nucleophilic substitution, amide coupling, and heterocycle formation. The methanesulfonyl group facilitates selective deprotection and acts as a reliable leaving group in cross-coupling reactions. Widely employed in API development, it functions effectively in both solution-phase and solid-phase workflows.
Synthesis
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Route1
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124-63-0 - ~97%
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In-stock
3144-09-0
References
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G. D. Searle and Company Patent: US6372758 B1, 2002 ; US 6372758 B1
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Route2
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624-90-8
- ~95%
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In-stock
3144-09-0
References
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Ramesha, A. R.; Bhat, Shridhar; Chandrasekaran, Srinivasan Journal of Organic Chemistry, 1995 , vol. 60, # 23 p. 7682 - 7683
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Route3
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286459-94-7
- ~92%
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In-stock
3144-09-0
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287379-32-2
References
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American Cyanamid Company Patent: EP1157024 B1, 2002 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 60.16
- LogP -1.0953
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 0
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