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Structure of 741721-51-7
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1-Bromo-2,5-difluoro-3-nitrobenzene features a trifunctional aromatic core with orthogonal reactivity. The bromine serves as a reliable coupling handle in cross-coupling reactions, while the electron-deficient ring enhances susceptibility to nucleophilic substitution. The para-fluorine and meta-nitro groups stabilize the intermediate and direct regioselective functionalization. This compound enables efficient access to complex fluorinated heterocycles and bioactive scaffolds under standard conditions.
1-Bromo-2,5-difluoro-3-nitrobenzene serves as a versatile building block for the synthesis of fluorinated heterocycles and functionalized aryl scaffolds. Its orthogonal reactivity—combining electrophilic bromine with electron-withdrawing nitro and fluorine substituents—enables palladium-catalyzed cross-couplings, nucleophilic aromatic substitution, and sequential functionalization. Bench-stable and compatible with standard purification methods, it facilitates efficient access to complex fluorinated intermediates in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: