5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole-3-carboxylic acid

Name: 5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole-3-carboxylic acid
Brand: ChemScene
Availability: InStock
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CAS No. 796729-10-7
Cat. No. CS-W007145
Purity≥97%
MDL No.MFCD11846937

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole-3-carboxylic acid|CS-W007145

Structure of 796729-10-7

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General Information

CAS No. 796729-10-7
Cat. No. CS-W007145
Purity ≥97%
MDL No. MFCD11846937
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₈N₂O₂
Molecular Weight 152.15
Synonym(s) 4H,5H,6H-pyrrolo[1,2-b]pyrazole-3-carboxylic acid
SMILES O=C(C1=C(CCC2)N2N=C1)O

Description

This pyrrolopyrazole carboxylic acid features a fused bicyclic core with a reducible dihydro moiety, enabling strategic functionalization at the 3-position. The carboxylic acid group provides a robust handle for derivatization, while the electron-rich heterocycle supports diverse synthetic transformations. Bench-stable and compatible with standard coupling protocols, this scaffold serves as a privileged building block in medicinal chemistry and bioactive molecule development.

Application

5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole-3-carboxylic acid serves as a versatile heterocyclic building block for medicinal chemistry and synthetic applications. The carboxylic acid functionality enables direct derivatization via amide coupling or esterification, while the fused dihydro-pyrrolopyrazole core provides structural rigidity and potential hydrogen bonding capacity. Its bench-stable nature and compatibility with standard functional group manipulations make it suitable for modular synthesis of bioactive scaffolds and pharmaceutical intermediates.

Synthesis

Route1
- 86477-10-3
- ~63%
- In-stock
  
  796729-10-7
References
- F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BAKER-GLENN, Charles; CHAN, Bryan K.; DOTSON, Jennafer; ESTRADA, Anthony; HEFFRON, Timothy; LYSSIKATOS, Joseph; SWEENEY, Zachary Kevin Patent: WO2013/164323 A1, 2013 ; Location in patent: Page/Page column 51 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 55.12
LogP 0.5275
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Key Words

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5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole-3-carboxylic acid

CAS No. 796729-10-7

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