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3-Bromoimidazo[1,2-a]pyridine-6-carboxylic acid

  • CAS No. 886362-00-1

  • Cat. No. CS-0060680
  • Purity≥95%
  • MDL No.MFCD07021511

*For research and further manufacturing use only, not for direct human use.

3-Bromoimidazo[1,2-a]pyridine-6-carboxylic acid|CS-0060680

Structure of 886362-00-1

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General Information

  • CAS No. 886362-00-1
  • Cat. No. CS-0060680
  • Purity ≥95%
  • MDL No. MFCD07021511
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅BrN₂O₂
  • Molecular Weight 241.04
  • Synonym(s) 2-a]pyridine-6-carboxylic acid
  • SMILES C1=CC2=NC=C(Br)N2C=C1C(=O)O

Description

3-Bromoimidazo[1,2-a]pyridine-6-carboxylic acid features a fused heterocyclic core with a bromine atom at the 3-position and a carboxylic acid group at the 6-position. This combination enables direct functionalization in cross-coupling reactions and facilitates conjugation to biomolecules or polymers. The molecule exhibits enhanced solubility in polar solvents and stability under standard bench conditions, making it suitable for use in medicinal chemistry and materials synthesis workflows.

Application

3-Bromoimidazo[1,2-a]pyridine-6-carboxylic acid serves as a versatile building block for constructing biologically active heterocyclic scaffolds. The carboxylic acid functionality enables direct amidation or esterification, while the bromo group facilitates palladium-catalyzed cross-coupling reactions. Its stability under standard bench conditions and compatibility with diverse functional groups make it suitable for iterative synthesis in medicinal chemistry and process development workflows.

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Computational Chemistry Data

  • TPSA   54.6
  • LogP   1.795
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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