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CS-W001157 4
Total: USD 88.00

(2-Fluorophenyl)methanamine

  • CAS No. 89-99-6

  • Cat. No. CS-W004092
  • Purity≥97%
  • MDL No.MFCD00008107

*For research and further manufacturing use only, not for direct human use.

(2-Fluorophenyl)methanamine|CS-W004092

Structure of 89-99-6

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General Information

  • CAS No. 89-99-6
  • Cat. No. CS-W004092
  • Purity ≥97%
  • MDL No. MFCD00008107
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈FN
  • Molecular Weight None
  • Synonym(s) 2-Fluorobenzylamine
  • SMILES FC1=CC=CC=C1CN

Description

(2-Fluorophenyl)methanamine features a fluorinated aromatic ring linked to a primary amine group, delivering enhanced electron-withdrawing character and improved metabolic stability. This bench-stable compound integrates readily into pharmaceutical scaffolds, offering favorable solubility and compatibility in synthetic transformations.

Application

(2-Fluorophenyl)methanamine serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic amines via standard coupling and functionalization reactions. Its bench-stable nature and compatibility with diverse reaction conditions facilitate efficient incorporation into biologically active scaffolds, including kinase inhibitors and CNS-targeted compounds.

Synthesis

  • Route1
    • null|null
      394-47-8
    • ~97%
    • In-stock
      (2-Fluorophenyl)methanamine|CS-W004092
      89-99-6

    References

    • Takamizawa; Wakasa; Fuchikami Synlett, 2001 , # 10 p. 1623 - 1625
  • Route2

    References

    • Organic Letters, , vol. 4, # 12 p. 2055 - 2058
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 49, # 21 p. 6197 - 6208

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.2844
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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