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CS-W001157 4
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(2,4-Difluorophenyl)methanamine

  • CAS No. 72235-52-0

  • Cat. No. CS-W018261
  • Purity≥97%
  • MDL No.MFCD00010142

*For research and further manufacturing use only, not for direct human use.

(2,4-Difluorophenyl)methanamine|CS-W018261

Structure of 72235-52-0

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General Information

  • CAS No. 72235-52-0
  • Cat. No. CS-W018261
  • Purity ≥97%
  • MDL No. MFCD00010142
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇F₂N
  • Molecular Weight 143.14
  • Synonym(s) 2,4-Difluorobenzylamine
  • SMILES NCC1=CC=C(F)C=C1F

Description

2,4-Difluorobenzylamine has been used in the synthesis of AlaAib(N-fluoroarylmethyl)], nonpolar nucleobase dipeptide via Ugi four-component condensation reaction.

Application

(2,4-Difluorophenyl)methanamine serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive scaffolds through standard amine coupling and electrophilic substitution reactions. Its fluorinated aryl core enhances metabolic stability and modulates electronic properties, while the primary amine facilitates conjugation with carboxylic acids, sulfonyl chlorides, and isocyanates. Bench-stable and readily purified by distillation or chromatography, it functions reliably in multi-step syntheses of pharmaceutical intermediates and functional materials.

Synthesis

  • Route1

    References

    • Werkmeister, Svenja; Bornschein, Christoph; Junge, Kathrin; Beller, Matthias Chemistry - A European Journal, 2013 , vol. 19, # 14 p. 4437 - 4440

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.4235
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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