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CS-W001157 4
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(6-Chloropyridin-3-yl)methanamine

  • CAS No. 97004-04-1

  • Cat. No. CS-W018542
  • Purity≥97%
  • MDL No.MFCD00673153

*For research and further manufacturing use only, not for direct human use.

(6-Chloropyridin-3-yl)methanamine|CS-W018542

Structure of 97004-04-1

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General Information

  • CAS No. 97004-04-1
  • Cat. No. CS-W018542
  • Purity ≥97%
  • MDL No. MFCD00673153
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇ClN₂
  • Molecular Weight 142.59
  • Synonym(s) 6-Chloro-3-picolylamine
  • SMILES ClC1=CC=C(CN)C=N1

Description

This bench-stable amine features a chloropyridyl moiety enabling direct functionalization in cross-coupling reactions. The para-chloro substitution enhances electrophilic reactivity, while the primary amine group facilitates conjugation and coordination in catalytic systems.

Application

(6-Chloropyridin-3-yl)methanamine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based scaffolds through standard coupling reactions. Its chloro group provides a reliable handle for palladium-catalyzed cross-coupling, while the primary amine facilitates derivatization via acylation, alkylation, or imine formation. The compound exhibits good bench stability and is compatible with common purification methods, making it well-suited for iterative synthesis campaigns in API development.

Synthesis

  • Route1
    • null|null
      1080018-12-7
    • ~92%
    • In-stock
      (6-Chloropyridin-3-yl)methanamine|CS-W018542
      97004-04-1

    References

    • Nippon Soda Co., Ltd. Patent: US2010/121054 A1, 2010 ; Location in patent: Page/Page column 9 ;
  • Route2

    References

    • WO2011/161615 A1, ; Page/Page column 58 ; WO 2011/161615 A1
  • Route3

    References

    • US5084459 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H317-H318-H335
Precautionary Statements : P261-P264-P270-P271-P272-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.1937
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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